Suggests that a western diet produces cognitive decline and neurodegeneration through augmented Na,K-ATPase signaling and that antagonism of this pathway in adipocytes ameliorates the pathophysiology.https://www.cell.com/iscience/fulltext/S2589-0042(21
These links worked better for me: summary
Note this is a mouse study.
"Mice were placed on a normal chow diet containing 11%
fat, 62% carbohydrate, and 27.0% protein with total calories of 12.6 KJ/g and had free
access to water or the mice were placed on WD containing 42% fat, 42.7 % carbohydrate,
and 15.2% protein yielding 4.5 KJ/g and had free access to water (Pratt et al., 2019)."
Doesn't make sense that the 11% fat diet would have total calories of 12.6 KJ/g and the 42% fat diet would have total calories of 4.5 KJ/g. Perhaps these are reversed? Anyways, mice don't do well on a high fat diet, this is well known. Not sure what this tells us about humans IMO.