Western diet may produce cognitive decline and neurodegeneration

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stana
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Western diet may produce cognitive decline and neurodegeneration

Postby stana » Thu Oct 14, 2021 12:23 am

Suggests that a western diet produces cognitive decline and neurodegeneration through augmented Na,K-ATPase signaling and that antagonism of this pathway in adipocytes ameliorates the pathophysiology.

https://www.cell.com/iscience/fulltext/S2589-0042(21)01231-1

Tincup
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Re: Western diet may produce cognitive decline and neurodegeneration

Postby Tincup » Thu Oct 14, 2021 8:04 pm

stana wrote:Suggests that a western diet produces cognitive decline and neurodegeneration through augmented Na,K-ATPase signaling and that antagonism of this pathway in adipocytes ameliorates the pathophysiology.

https://www.cell.com/iscience/fulltext/S2589-0042(21)01231-1


These links worked better for me: summary and PDF

Note this is a mouse study.

"Mice were placed on a normal chow diet containing 11%
fat, 62% carbohydrate, and 27.0% protein with total calories of 12.6 KJ/g and had free
access to water or the mice were placed on WD containing 42% fat, 42.7 % carbohydrate,
and 15.2% protein yielding 4.5 KJ/g and had free access to water (Pratt et al., 2019)."

Doesn't make sense that the 11% fat diet would have total calories of 12.6 KJ/g and the 42% fat diet would have total calories of 4.5 KJ/g. Perhaps these are reversed? Anyways, mice don't do well on a high fat diet, this is well known. Not sure what this tells us about humans IMO.
Tincup
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