Nikki2019 wrote:Pardon my ignorance, I am still in the learning process now...
I wonder if since mitochondria is inherited maternally, does this mean that there have been any studies that show if the apoE4 is from father then it is not contributing towards the AD risk? I guess they'd need to have subjects that are heterozygous and study weather it makes a difference if the 4 comes from mom or dad.
We are all learning together! Not sure anyone knows the answer to your mitochondrial/E4 question, but here is my anecdotal story:
I have 2 E4s, one from father and one from mother. I've had low energy for at least a year. My mother must have great mitochondria: she is 83 years old, lives alone, does much of her own yard work, goes to Silver Sneakers a few times a week, etc. She kept up on a 5 mile walk with me and my husband this summer when we visited her. On the other hand, my father died at age 69 of what was probably a massive heart attack, had a strong family history of coronary artery disease (CAD), and had very low energy the last few years of his life (cardiac related or mitochondria? Maybe both). The only known family member with AD is my brother who is currently 61; he has my mother's mitochondria and unknown E4 status.
More questions than answers...
If your brother has kids, they may find it useful to get his 23andme health info, easy enough to spit and send it off. He is on the young side. I wonder about everyones E4 status now, even in my gym class this morning! Not that I outwardly ask folks.
Your mom has great mitochondria, but brother didn't get the results she has. Your ma has at least one E4, maybe 2? She has somehow avoided the AD, maybe with lifestyle choices that differ from brother? Just thinking out loud... the E4 allele is outside of the mitochondria so even if one has no AD or allele from mom's side and it is from dad, then it seems that it would not make a difference anyway? The wikpedia page I read mentions something about AD being more likely if its from mom rather than dad.
I do have some " senior moments" but had them even at age 20. Teens have the worst senior moments. I do get the afternoon sleepiness, but doesn't everyone? I read somewhere in a book that it's best to have medical procedures done in the morning, because errors are a lot more likely in the late afternoon because of fatigue ( all folks not just E4s). That being said, after seeing what my father has gone through with AD is no joke, so I am being proactive.
The prevention measures that I have implemented thus far have not been a sacrifice to my happiness YET. I find the IF easy. If I need to completely give up cheese- then we'll cross that bridge then. It's still around three weeks til New Year 2020 resolutions!