Hormone Replacement Therapy E4 Women

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
judith74
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Re: Hormone Replacement Therapy E4 Women

Post by judith74 »

Hello
I have read the 42 pages in this topic, thanks for all the information! I am ApoE 3 /4, and 43 years old, I’ve had some perimenopause symptoms (sleep problems and maybe some night sweats) and I think it would be worth it to try the BHRT. I have an appointment with a gynecologist next week and I would like to do my homework and to have a clear idea of what I want before going to him, and what do I need to be aware of. For example I did not had any idea about BHRT before reading it here! Now I know that I need to ask for BHRT not just HRT. Both my parents died too young, my dad died for colon cancer at 71, and my mom for a stroke at 70. Not breast cancer in the family…yet. I am healthy, thin and following most of the healthy advice that I have found here :)

I would like to ask you 1) what do you think are the principal aspect to consider when deciding to take or not to take the BHRT. And 2) could you recommend some papers that in your opinion have good information that could help to make an informed decision.

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Julie G
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Re: Hormone Replacement Therapy E4 Women

Post by Julie G »

God bless you, judith74. That thread, while chockfull of information, is an iconic representation of our collective work that badly needs to be distilled to a short wiki post. I can point you to a very concise primer written by Dr. Ann Hathaway, while not E4 specific, clearly lays out the benefit (while addressing the risks) for all women in using bHRT to stave off cognitive decline. Dr. Hathaway provides many references that you may find helpful in sharing with your physician. You could supplement with a few key E4+ papers from the longer thread.

Before I began bHRT, I mistakenly assumed that it would be prohibitively expensive, had to be compounded, and paid for out-of-pocket. Thankfully, that's not proven true for many here. Most of my products (Minivelle .1mg, Estrace cream, Progesterone 100 mg, Testim gel (with the exception of the testosterone gel) have been regular prescriptions covered by insurance. The Testim isn't covered because the medical usage for women is to improve libido which isn't considered "medically necessary." Funny that Viagra is ;). LOL, apologies for my side rant.
judith74
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Re: Hormone Replacement Therapy E4 Women

Post by judith74 »

Thank you Juliee!! It is good to know that the compound is not the only option.

I’ll see what we have in Canada. Thanks for the information about what is what you are taking, and more important about the Testim…I wanted to know about something that could help in that area, but I was embarrass to ask :oops: :D

Judith
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Re: Hormone Replacement Therapy E4 Women

Post by Nancy »

Hello, all...I am back with some news. Not good! I just found out I have a planum sphenoidale meningioma (brain tumor, probably benign, between my brain hemispheres, in the front of my head, between my optic nerves). It is 1.5 X 1.5 cm. It was found at a standing ER center I went to last week due to persistent headaches, nausea (I rarely get headaches). I have had a ct scan and MRI but am still waiting to hear from my neurosurgeon. I haven't yet, at all :|. Since I'm having some symptoms, I'm guessing it will be surgically removed. My vision may be at risk, otherwise (although, the surgery itself carries risks, too). The reason I'm posting here is because I have been researching meningiomas A LOT these last few days, and there are several studies that show a link between HRT and benign brain meningiomas (if you google progesterone and meningioma, you can find a list of studies). Women are twice as likely to have them, and this is what caused the studies to be done. Apparently, more than half the time benign brain meningiomas have been found to be full of progesterone receptors. I have been taking the progesterone for a while now (8 months) because it is supposed to be helpful in preventing AD, but I'm thinking I should probably wean myself off now. I feel kind of conflicted. It's a catch 22, it seems. A benign tumor might not sound so terrible, but depending on it's location, it sure can be! Also, just thought if you are taking or considering taking progesterone, it's good to know this potential risk when making your decision. Oh, the good news: no Alzheimer's was seen in the brain scans...so these measures I've been taking here are working well in that regard!
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Julie G
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Re: Hormone Replacement Therapy E4 Women

Post by Julie G »

{{{Nancy}}} I'm sending lots of love and good energy your way. I have no idea if progesterone could be contributing, but would follow the advice of your oncologist. Please keep us posted on your treatment plan. xo
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SusanJ
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Re: Hormone Replacement Therapy E4 Women

Post by SusanJ »

Hugs, Nancy. Sending healing energy your way.
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KatieS
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Re: Hormone Replacement Therapy E4 Women

Post by KatieS »

Nancy, sending positive thoughts your way going thru such an ordeal. Please feel free to keep us posted (or not). Eyes are a hot button for me, increased with some recent ongoing problems. I just can't imagine how scary this must be for you. From my reading, the E4 seems to lower our risks for brain cancer.
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TheBrain
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Re: Hormone Replacement Therapy E4 Women

Post by TheBrain »

{{{Nancy}}} I'm so sorry you have this tumor. I'm sending waves and waves of positive energy your way and wishing you the very best on this entirely new aspect of your health journey. And thank you for alerting us to the link between this type of tumor and progesterone. I'll certainly investigate this link further. Please keep us posted on your treatment and how you're doing.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!
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Re: Hormone Replacement Therapy E4 Women

Post by Lucy5 »

Nancy, sending hugs and tons of positive thoughts your way!! It was so thoughtful of you to share your concerns about unknown/possible progesterone risks for anyone here who would like to investigate further. Please keep us posted on how you're doing, we're all here for you.
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Re: Hormone Replacement Therapy E4 Women

Post by Sandy57 »

Get well Nancy, sending positive energy your way.

Aloha Frank and Sandy
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