Our first guest: Dr. Thomas Dayspring...
Posted: Tue Feb 24, 2015 3:01 pm
I want to give full props to Thumperama for recommending & setting up this initiative. Over the coming weeks, as time permits (day job!) he plans to query some top experts in the field of AD/CAD (as well as various health personalities) regarding some of our unanswered questions. Those who've been here long enough realize that there is a tremendous lack of peer reviewed science providing APOE ε4 carriers with a consensus on preventing either disease. Even more frustrating, the advice from experts is often wildly contradictory. Our activism on this initiative will hopefully begin to move the scientific community towards conducting potentially lifesaving research on our behalf. In the meantime, our goal is to get some top minds working on this puzzle with us.
Our secondary goal is to get these folks to work with us free of charge Some may ask to be compensated; we'll deal with that as it arises. Ultimately, we'd like to establish an ongoing Q & A opportunity. perhaps a podcast featuring a variety of experts.
Our first guest expert will be Dr. Thomas Dayspring. He's generally considered to be the top lipidologist in the U.S. Here's a link to his bio where you can also download his complete CV: http://www.biomarkerbliki.org/author/5
We've come up with three questions that he's agreed to answer without being compensated. Here are the questions:
1. Is there a general dietary recommendation that you would give to ApoE 4 variant individuals (and are there differences between a 3/4 and a 4/4) to reduce their likelihood of Alzheimer’s Disease/dementia and cardiovascular disease. It’s quite common for members of the ApoE4.info forums to take one of two paths to address their disposition to these diseases:
Strategy A: Focus on strictly lowering dietary fat to address our population's tendency towards higher LDL-C/P. Some hypothesize that this may also prevent amyloid plaque deposition. Some members who employ this strategy are also vegetarians/vegans. Rice and/or beans are often staples. Caloric restriction is sometimes concurrently employed to avoid insulin resistance.
Strategy B: Focus on increasing healthy fats (MUFAs, nuts) to address/prevent insulin resistance and induce mild ketosis. Members who employ this strategy tend to be omnivores, who eat small amounts of proteins rich in Omega-3s and plentiful non-starchy vegetables. Many of these members concurrently employ caloric restriction to overcome our propensity for higher LDL-C/P and to further enhance mitochondrial function.
2. Given the recent research that suggests it’s the amount and function of an individual's ApoE that convey dementia risks rather than the underlying genotype, do you have suggestions for how individuals concerned about this should go about testing for ApoE and therapies that may benefit them by increasing the ApoE levels?
3. If ALL other risk factors are minimized (high HDL-C/P, low glucose markers and inflammation markers, low Lp[a]); is it OK for those who carry an E4 variant to have slightly higher LDL-P/ApoB?
I'm looking forward to Dr. Dayspring's thoughts on these questions. Thumperama will post them as soon as he receives the reply.
Our secondary goal is to get these folks to work with us free of charge Some may ask to be compensated; we'll deal with that as it arises. Ultimately, we'd like to establish an ongoing Q & A opportunity. perhaps a podcast featuring a variety of experts.
Our first guest expert will be Dr. Thomas Dayspring. He's generally considered to be the top lipidologist in the U.S. Here's a link to his bio where you can also download his complete CV: http://www.biomarkerbliki.org/author/5
We've come up with three questions that he's agreed to answer without being compensated. Here are the questions:
1. Is there a general dietary recommendation that you would give to ApoE 4 variant individuals (and are there differences between a 3/4 and a 4/4) to reduce their likelihood of Alzheimer’s Disease/dementia and cardiovascular disease. It’s quite common for members of the ApoE4.info forums to take one of two paths to address their disposition to these diseases:
Strategy A: Focus on strictly lowering dietary fat to address our population's tendency towards higher LDL-C/P. Some hypothesize that this may also prevent amyloid plaque deposition. Some members who employ this strategy are also vegetarians/vegans. Rice and/or beans are often staples. Caloric restriction is sometimes concurrently employed to avoid insulin resistance.
Strategy B: Focus on increasing healthy fats (MUFAs, nuts) to address/prevent insulin resistance and induce mild ketosis. Members who employ this strategy tend to be omnivores, who eat small amounts of proteins rich in Omega-3s and plentiful non-starchy vegetables. Many of these members concurrently employ caloric restriction to overcome our propensity for higher LDL-C/P and to further enhance mitochondrial function.
2. Given the recent research that suggests it’s the amount and function of an individual's ApoE that convey dementia risks rather than the underlying genotype, do you have suggestions for how individuals concerned about this should go about testing for ApoE and therapies that may benefit them by increasing the ApoE levels?
3. If ALL other risk factors are minimized (high HDL-C/P, low glucose markers and inflammation markers, low Lp[a]); is it OK for those who carry an E4 variant to have slightly higher LDL-P/ApoB?
I'm looking forward to Dr. Dayspring's thoughts on these questions. Thumperama will post them as soon as he receives the reply.