Since I have the bad MAPT polymorphism for the tau I am relieved that my Klothos variant may yet save my brain. (Grateful for my little 3% Ashkenazi Jewish roots, wherever they came from...)
From Gladstone, posted February 10, 2015 -
Protein Linked to Longevity and Enhanced Cognition Also Protects Against Alzheimer’s Symptoms
Increasing klotho in Alzheimer mice improved their cognitive function in spite of disease-causing proteins in the brain
This is actually great news even for those without the natural Klothos variant as it seems promising that they will devise a drug that is similar in effect.
“The next step will be to identify and test drugs that can elevate klotho or mimic its effects on the brain,” says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease and the Joseph B. Martin Distinguished Professor of Neuroscience at UCSF. “We are encouraged in this regard by the strong similarities we found between klotho’s effects in humans and mice in our earlier study. We think this provides good support for pursuing klotho as a potential drug target to treat cognitive disorders in humans, including Alzheimer’s disease.”
I needed some good news today.