While he was working at Henry Wellcome Laboratories, Nobel Laureate Sir Henry Dale discovered that histamine was released during anaphylaxis, a lifethreatening allergic reaction. This is a very complex, severe reaction, and apparently acetyl choline and heparin are also involved. Guinea pigs are very sensitive to anaphylactic shock. Boyle found that if guinea pigs were pretreated for a week with niacin, they did not die after a second dose of protein— a procedure that killed all the animals not pretreated. I have used this technique to protect patients against anaphylactic shock. In 1996 I saw a man who was very fearful for his life. He was peanut sensitive and avoided all traces of peanuts, but over a six-month period he had five major reactions and nearly died from the last one. I advised him to start with ascorbic acid, 1 gram taken after each of three meals. Ascorbic acid destroys histamine, which is why scorbutic patients who are deficient in this vitamin have high blood histamine levels. I wanted to build up his blood ascorbic acid levels. After one week he was to take 100 mg of niacin three times daily after meals. This was designed to release a small amount of histamine with a gentle flush. My hypothesis was that the histamine would be destroyed by the ascorbic acid and would therefore be neutralized to a degree. The niacin dose was increased to 250 mg twice a day . This was his maintenance dose. He came back ten years later for an unrelated problem. He had not taken any niacin the previous two years after his doctor told him to stop. (This is an example of a totally illogical fear of niacin when the same doctor would, with no hesitation, prescribe any and all of the toxic drugs that are available.) I advised him to resume the niacin and to increase the dose until he was on 1 gram after each of three meals. He had no more reactions. I had advised him to be as careful as before. I have also used the combination of niacin and ascorbic acid to protect patients against the hives induced by insect bites. And I found it very helpful in decreasing the intensity of the allergic reactions, no matter what type of substance the patient is reacting to, although it will not completely prevent these reactions.
Hoffer, Abram; Andrew W. Saul; Harold D. Foster (2012-02-01). Niacin: The Real Story (Kindle Locations 815-830). Basic Health Publications, Inc.. Kindle Edition.
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