It looks like someone just had an epiphany: This Alzheimer thing could go large.http://www.alzforum.org/news/community- ... 60-percent
It could go very very large. The link talks about saving hundreds and hundreds of billions of dollars with
even a partially effective treatment. Congress has just stepped forward with $350 million in incremental
funding. Apparently someone has just realized that the massive wave of dementia is heading directly towards
us at high speed. It's "Batten down the hatches!" time ...finally.
I think if I were sitting in the big chair right now, I'd be thinking of doing some sort of Alzheimer Exome Project.
It would make a whole bunch of sense to me. The genetics of Familial Alzheimer's is nearly a complete mystery.
Finally determining what specific variants and pathways lead to dementia could be overwhelmingly helpful.
Item number one would probably be to sequence the entire early onset population of Colombia.
Doing some large scale exome/genome sequencing in the States would also be high on the
list. An Alzheimer Genetics Project with a budget of $25 million might finally unlock the
biology behind dementia. At some point they would be able to make an inexpensive dementia
gene chip that could provide comprehensive coverage of the risk and protective variants.