The role of ApoE and its isoforms in the ketogenic state is relatively unknown. In contrast to the high-fat diet, we found no change in hippocampal ApoE levels in response to ketogenic diet for any genotype. However, we did observe an interesting effect of ketogenic diet on plasma ApoE, with ApoE4 mice having a large increase in plasma ApoE in response to ketosis, while ApoE3 mice experienced a more moderate change. [Empasis mine]
Stavia wrote:As regards the paper, I'd like to know exactly what the furry friends were fed before commenting. All fat is certainly not equal. And rodent diets do not always extrapolate well to humans.
[/quote]Two interpretations are possible from our findings: either the high-fat diet-induced reduction in ApoE is itself harmful for brain function, or it is a protective adaptive response.
Yum yum! Lard!!75% fat, 8.6% protein, 3.2% carbohydrate, lard- and butter-based, AIN-76A-Modified from Bio Serv
Surprisingly, in contrast to the wildtype mice, we found that a high-fat diet significantly reduced levels of hippocampal human ApoE in ApoE3 TR mice, but not ApoE4 TR mice.
In our experiments, we found a similar trend towards reduction of hippocampal ApoE in ApoE4 TR mice, which did not achieve significance. That said, it is tempting propose a model by which a high-fat diet brings levels of ApoE3 down to ApoE4 baseline levels.
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