new research

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
User avatar
Russ
Senior Contributor
Senior Contributor
Posts: 566
Joined: Fri Feb 07, 2014 10:33 am

Re: new research

Postby Russ » Sun Feb 07, 2016 1:08 pm

Seems to me that although less emphasized in the article, perhaps even more significant than reduction in hippocampal APOE levels on high fat diet - esp for E3's - is the observation that plasma APOE levels are very substantially increased on ketogenic diet and differentially so for E4's.

I've put all the data on one pair of charts for ease of understanding....
Slide1.jpg

Potential significance and implications?
You do not have the required permissions to view the files attached to this post.
Last edited by Russ on Mon Feb 08, 2016 7:34 am, edited 1 time in total.
Russ
E3/4
Eat whole, real, flavorful food - fresh and in season... and mix it up once in a while.

J11
Contributor
Contributor
Posts: 1844
Joined: Sat May 17, 2014 4:04 pm

Re: new research

Postby J11 » Sun Feb 07, 2016 2:40 pm

Now that is very interesting!
I have been trying all day to remember what greatly moved up APOE levels.
Thank you for the reminder: Ketogenesis!

Might this be why Axona works best in APOE e3s?

Would be very very interested to see what might happen with the triple
combo treatment of ketosis, DHA and bexarotene.

Online
circular
Senior Contributor
Senior Contributor
Posts: 5221
Joined: Sun Nov 03, 2013 10:43 am

Re: new research

Postby circular » Sun Feb 07, 2016 4:01 pm

A landmark n=1 review concludes I'm more confused than ever.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

User avatar
Russ
Senior Contributor
Senior Contributor
Posts: 566
Joined: Fri Feb 07, 2014 10:33 am

Re: new research

Postby Russ » Mon Feb 08, 2016 7:44 am

OK, this study seems relevant to my above comment....

http://www.medscape.com/viewarticle/812097

"We found that low plasma levels of APOE associate with risk of dementia, and we found that low plasma levels of APOE associate with risk of dementia independent of APOE gene type," Dr. Rasmussen concluded.


Could it be that driving up plasma levels of APEO is key for us E4's in combination with some kind of equilibrium/non-suppressed levels in the brain?

PS: Would LOVE to see this same (originally linked) study repeated for different industrial vs natural (pastured/grassfed) fat (e.g. lard, tallow, butter) sources.

Russ
Russ
E3/4
Eat whole, real, flavorful food - fresh and in season... and mix it up once in a while.

User avatar
Julie G
Mod
Mod
Posts: 8684
Joined: Sat Oct 26, 2013 6:36 pm

Re: new research

Postby Julie G » Mon Feb 08, 2016 8:22 am

Great graph- Russ, Thank you! Visually seeing the evidence is very helpful. Perhaps the plasma vs. hippocampal APOE is a red herring given this strong association (between plasma APOE and dementia) in humans from your link?
When the nearly 76,000 participants were divided into APOE tertiles, the cumulative incidence of Alzheimer's disease with age was significantly associated with APOE level.

"We found a 3-fold increased risk for the lowest tertile versus the highest tertile and a highly significant P [value] for trend, and the association remained after further adjustment for the APOE genotype," Dr. Rasmussen reported (log-rank trend P < .001).

I seem to recall multiple papers concluding the same with regard to the association between APOE levels and risk of dementia. I'll poke around and see what I can find...

User avatar
LG1
Senior Contributor
Senior Contributor
Posts: 362
Joined: Fri Dec 18, 2015 10:32 am
Location: Dallas, TX

Re: new research

Postby LG1 » Mon Feb 08, 2016 7:23 pm

You guys are awesome!

I found the article myself this evening and so went to to see if anyone was talking about it here and sure enough! This is extremely interesting to me as I am on a keto diet 95% of the time and have been for several months.

Looking forward to more of everyone's input!

Laura
ε4/ε4 vaccinated 2/21

User avatar
LG1
Senior Contributor
Senior Contributor
Posts: 362
Joined: Fri Dec 18, 2015 10:32 am
Location: Dallas, TX

Re: new research

Postby LG1 » Mon Feb 08, 2016 7:40 pm

Juliegee wrote:...I couldn't resist sharing this old chestnut from Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy. It's a nice graphic summary of both the ApoE4 loss of function AND toxic gain-of-function
nihms492068f3.gif


Thanks for the link to the article, Julie...

Can someone please confirm this says what I think it says?!

The frequency of AD and mean age at clinical onset are 91% and 68 years of age in ε4 homozygotes, 47% and 76 years of age in ε4 heterozygotes, and 20% and 84 years in ε4 noncarriers,7, 20 indicating that APOE ε4 confers dramatically increased risk of development of AD with an earlier age of onset in a gene dose-dependent manner (Figure 1b).


Are they saying 91% of E4/4's will have AD by age 68?

Thanks........... :shock:
ε4/ε4 vaccinated 2/21

User avatar
LG1
Senior Contributor
Senior Contributor
Posts: 362
Joined: Fri Dec 18, 2015 10:32 am
Location: Dallas, TX

Re: new research

Postby LG1 » Mon Feb 08, 2016 8:17 pm

Russ wrote:Seems to me that although less emphasized in the article, perhaps even more significant than reduction in hippocampal APOE levels on high fat diet - esp for E3's - is the observation that plasma APOE levels are very substantially increased on ketogenic diet and differentially so for E4's.

I've put all the data on one pair of charts for ease of understanding....
Slide1.jpg

Potential significance and implications?


Russ, (or Stavia or Julie or anyone else that knows) I'm a little behind the learning curve on this but trying... can you explain what it means for E4/4's? I am confused as to what is considered 'good' on the chart here. Hippocampal APOE levels.... Should they be high or low? Am I right in understanding it is 'good' for the APOE plasma levels to be high?

Thanks!
ε4/ε4 vaccinated 2/21

J11
Contributor
Contributor
Posts: 1844
Joined: Sat May 17, 2014 4:04 pm

Re: new research

Postby J11 » Mon Feb 08, 2016 9:31 pm

Sorry to take this off topic, though I wanted to see if anyone might make sense of this.

Looks like there is a histidine/histamine deficit in AD.
https://www.ncbi.nlm.nih.gov/pubmed/2713757

Lack of histidine could lead to copper trouble
http://www.ncbi.nlm.nih.gov/pubmed/24435851

User avatar
Julie G
Mod
Mod
Posts: 8684
Joined: Sat Oct 26, 2013 6:36 pm

Re: new research

Postby Julie G » Mon Feb 08, 2016 10:28 pm

LGI, I try not to overly focus on statistical predictions. They're truly all over the place. If it's any comfort, that 91% is a lifetime risk. It doesn't mean that 91% of us homozygotes will develop AD by age 68.
Russ, (or Stavia or Julie or anyone else that knows) I'm a little behind the learning curve on this but trying... can you explain what it means for E4/4's? I am confused as to what is considered 'good' on the chart here. Hippocampal APOE levels.... Should they be high or low? Am I right in understanding it is 'good' for the APOE plasma levels to be high?

According to Dr. Rasmussen, author of the paper below, low levels of apoE are associated with future risk of developing dementia. This conclusion is based upon an enormous dataset- almost 76,000 people...quite impressive. This paper has been cited by 10 others. Scroll to the bottom of the link above to see them.

Plasma Levels of Apolipoprotein E and Risk of Dementia in the General Population
https://www.researchgate.net/publicatio ... Population

J11, thanks. I'm looking forward to following up on those links!


Return to “Science and Research”

Who is online

Users browsing this forum: No registered users and 12 guests