"We found that low plasma levels of APOE associate with risk of dementia, and we found that low plasma levels of APOE associate with risk of dementia independent of APOE gene type," Dr. Rasmussen concluded.
When the nearly 76,000 participants were divided into APOE tertiles, the cumulative incidence of Alzheimer's disease with age was significantly associated with APOE level.
"We found a 3-fold increased risk for the lowest tertile versus the highest tertile and a highly significant P [value] for trend, and the association remained after further adjustment for the APOE genotype," Dr. Rasmussen reported (log-rank trend P < .001).
Juliegee wrote:...I couldn't resist sharing this old chestnut from Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy. It's a nice graphic summary of both the ApoE4 loss of function AND toxic gain-of-function
The frequency of AD and mean age at clinical onset are 91% and 68 years of age in ε4 homozygotes, 47% and 76 years of age in ε4 heterozygotes, and 20% and 84 years in ε4 noncarriers,7, 20 indicating that APOE ε4 confers dramatically increased risk of development of AD with an earlier age of onset in a gene dose-dependent manner (Figure 1b).
Russ wrote:Seems to me that although less emphasized in the article, perhaps even more significant than reduction in hippocampal APOE levels on high fat diet - esp for E3's - is the observation that plasma APOE levels are very substantially increased on ketogenic diet and differentially so for E4's.
I've put all the data on one pair of charts for ease of understanding....
Potential significance and implications?
Russ, (or Stavia or Julie or anyone else that knows) I'm a little behind the learning curve on this but trying... can you explain what it means for E4/4's? I am confused as to what is considered 'good' on the chart here. Hippocampal APOE levels.... Should they be high or low? Am I right in understanding it is 'good' for the APOE plasma levels to be high?
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