Very interesting, I finally got around to checking on this. I'm rs174548 (gg) and rs1535 (gg). I'm also ct @ rs7946.
Lately, I'm getting around 375mg/d of choline (some days without meat or eggs, I'm down around 200mg/d) and getting some salmon in once a week or so (occasionally 3x a week, occasionally 0x a week.) I've been turning down the carb intake and replacing with fats (while favoring unsaturated fats > saturated), which has really brought up my omega-6 intake. Lately, I've been including more flax / chia / hemp in my diet to somewhat balance the scale and maintain an overall 4:1 n-6:n-3 ratio, but this might only be serving to further increase polyunsaturated fats and the potential for easier lipid peroxidation. It seems like I might want to rethink my choline / omega-3 regimen (I've been avoiding these with potential TMAO issues surrounding higher intakes of choline and potential cholesterol issues with supplementing omega-3's as an E4.) I've read that higher intakes of PUFAs can require higher intakes of vitamin E (yet E supplementation might be associated with inflammation / cancer) + CoQ10 (ubiquinone vs ubiquinol?)
Maybe a doctors best Phosphatidylserine (100mg) + GPC (300mg) supplement (daily?) + 1g DHA/EPA (2g/d algae oil?) + tocotrienols (occasionally?) + CoQ10 (MicroActive Ubiquinone CoQ10 with PQQ?) + Meriva Curcumin (to increase FADS2 enzyme activity.) Although, this seems a bit heavy on the supplemental antioxidant front (especially if I get some vitamin C going in there.) It seems like I've also read that Uridine stacks well with Choline+DHA (+folate, which I'm already taking as a homozygous MTHFR, which stacks well with b12.) Hmmm..
Or, I suppose I could just eat more fish, meat, organs, and eggs.