PharmacistCatherine wrote:concerns about recommending LCHF diets that do not restrict saturated fats without first testing for the ApoE4 alleles.
This is your issue, right Catherine? You're concerned about negatively affecting the health of ApoE4 carriers?
In my opinion, for this to be an ethical concern for any study, one would need scientifically convincing evidence that
- LCHF diets with ad libitum saturated fat consumption affect ApoE4 carriers differently, and
- those differential effects across the study duration significantly damage health in those ApoE4 carriers.
I think both A
are open questions with credible conflicting evidence. Also, that you're not imposing
a saturated fat requirement - you're simply electing not to restrict it - relieves any potential ethical burden even more.
For a recent discussion of LDL and all cause mortality, I recommend this topic
. And this post
within that topic is where I came to grips with an unwarranted assumption on my part regarding A