Anti-inflammatory drug reverses memory loss in Alzheimer’s-disease-model mice

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LG1
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Re: Anti-inflammatory drug reverses memory loss in Alzheimer’s-disease-model mice

Post by LG1 »

When searching for mefenamic acid I found: https://en.wikipedia.org/wiki/Mefenamic_acid

"While studies have been conducted to see if mefenamic acid can improve behavior in transgenic mouse models of Alzheimer's disease[16][17] there is no good evidence that mefenamic acid or other NSAIDs can treat or prevent Alzheimer's in humans; clinical trials of NSAIDs other than mefenamic acid for treatment of Alzheimer's have found more harm than benefit.[18][19][20]"

Following up on the papers mentioned it seems Wiki tries to lump all NSAIDs together. Does mefenamic acid have a special property or do all NSAIDs work on the same NLRP3 inflammasome pathway?
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marty
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Re: Anti-inflammatory drug reverses memory loss in Alzheimer’s-disease-model mice

Post by marty »

Thanks.
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