This is logical, and in the absence of solid countervailing evidence, I'm going to target those levels. Of course, if hemoglobin / hematocrit lab tests show anemia, I'll boost iron incrementally until the anemia resolves.Overall, the answer to this question appears to be lower the better, provided anaemia is not the result.
Kathleen1 wrote:"The study found that in cognitively normal people who express the APOE ε4 risk allele, high CSF ferritin almost perfectly predicted whether the individual will experience cognitive decline in the subsequent 7 years," said Dr Bush.
The effect of ferritin "was far greater than the most established biomarkers — tau and amyloid β," he said.
Their results also showed that APOE ε4 carriers who have low iron levels were protected from cognitive decline."
Will see if I can find the article but if someone else does, feel free to comment. Note this is CSF iron. I do not know how this compares to blood levels.
MAC wrote:Perturbed Iron Distribution in Alzheimer’s Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis
"In conclusion, from our current study we provide convincing and extended evidence that AD is accompanied by iron overload in specific brain regions and iron deficiency in serum."
So lower serum iron is associated with AD? Again, could be biomarker of disease progression.
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