. This is the first to directly link cerebral glucose hypometabolism to cognitive deficits, tau neuropathy & synaptic dysfunction. This is of particular importance to our genotype as E4 carriers (in a dose dependent fashion) exhibit decrease glucose utilization as early as ups 20s and 30s. Here's the press release: Glucose deprivation in the brain sets stage for Alzheimer's disease, study shows
https://medicalxpress.com/news/2017-01- ... eimer.html
Here's the paper with full-text.
Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
http://www.nature.com/tp/journal/v7/n1/ ... 6296a.html
Abstract:
Clinical investigations have highlighted a biological link between reduced brain glucose metabolism and Alzheimer’s disease (AD). Previous studies showed that glucose deprivation may influence amyloid beta formation in vivo but no data are available on the effect that this condition might have on tau protein metabolism. In the current paper, we investigated the effect of glucose deficit on tau phosphorylation, memory and learning, and synaptic function in a transgenic mouse model of tauopathy, the h-tau mice. Compared with controls, h-tau mice with brain glucose deficit showed significant memory impairments, reduction of synaptic long-term potentiation, increased tau phosphorylation, which was mediated by the activation of P38 MAPK Kinase pathway. We believe our studies demonstrate for the first time that reduced glucose availability in the central nervous system directly triggers behavioral deficits by promoting the development of tau neuropathology and synaptic dysfunction. Since restoring brain glucose levels and metabolism could afford the opportunity to positively influence the entire AD phenotype, this approach should be considered as a novel and viable therapy for preventing and/or halting the disease progression. [Emphasis mine.]
