Polygenic info used to identify risk of AD

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jkramer65
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Re: Polygenic info used to identify risk of AD

Postby jkramer65 » Wed Nov 21, 2018 11:02 am

MarcR wrote:
jkramer65 wrote:
MarcR wrote:Yes, my suggestion quoted above is particular to the other member's situation in which having one E4 is already a given.

But I mean CC AND CC so if you are CC at rs7412 and a CC at rs429358 isn't that a 4/4?
So CC alone with rs7412 is one copy of an e4 correct?

What am I not getting?
The member had EXACTLY one E4. She already knew that she was NOT a 4/4. This implies that she is CT at rs429358. With that fact as a given, the other options, 2/4 and 3/4, can be distinguished by looking only at rs7412. I used the chart at the SNPedia APOE page to figure that out for her.


AH Thanks. Sorry. I might have Alzheimer's! lol. at least not yet anyway. hehe.

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MarcR
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Re: Polygenic info used to identify risk of AD

Postby MarcR » Wed Nov 21, 2018 11:30 am

An update:

MarcR
ApoE carrier status: 3/4
Polygenic Hazard Score: 88
AZ50: 86
Current age: 55
Cognitive status: (intact, SCI, MCI, early, mid, late): intact
Age of onset: N/A

MarcR father
ApoE carrier status: 3/4
Polygenic Hazard Score: 89
AZ50: 86
Current age: 78
Cognitive status: mid
Age of onset: 63

jkramer65
ApoE carrier status: 4/4
Polygenic Hazard Score: 100
AZ50: 80
Current age: 53
Cognitive status: intact
Age of onset: N/A

MyDestinyisfromGod
ApoE carrier status: 3/4
Polygenic Hazard Score: 93
AZ50: 86
Current age: 53
Cognitive status: intact
Age of onset: N/A

Plumster
ApoE carrier status: 3/4
Polygenic Hazard Score: 81
AZ50: 87
Current age: 49
Cognitive status: intact
Age of onset: N/A

Flyin66
ApoE carrier status: 4/4
Polygenic Hazard Score: 99
AZ50: 80
Current age: early 50s
Cognitive status: intact
Age of onset: N/A

mike
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Re: Polygenic info used to identify risk of AD

Postby mike » Wed Nov 21, 2018 11:57 am

So just looking at the pattern, if you are 4/4, your Hazard score goes to 99-100% with a 50% chance of having AD by 80 years old, where as 3/4's Hazard scores vary between 81 and 93 with 50% not until 86 years old. Does that mean that 3/4s have a better chance of changing their likelihood of getting AD than 4/4s based on lifestyle changes?
Sonoma Mike
4/4


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