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Re: Polygenic info used to identify risk of AD

Posted: Wed Nov 21, 2018 11:02 am
by jkramer65
MarcR wrote:
jkramer65 wrote:
MarcR wrote:Yes, my suggestion quoted above is particular to the other member's situation in which having one E4 is already a given.
But I mean CC AND CC so if you are CC at rs7412 and a CC at rs429358 isn't that a 4/4?
So CC alone with rs7412 is one copy of an e4 correct?

What am I not getting?
The member had EXACTLY one E4. She already knew that she was NOT a 4/4. This implies that she is CT at rs429358. With that fact as a given, the other options, 2/4 and 3/4, can be distinguished by looking only at rs7412. I used the chart at the SNPedia APOE page to figure that out for her.
AH Thanks. Sorry. I might have Alzheimer's! lol. at least not yet anyway. hehe.

Re: Polygenic info used to identify risk of AD

Posted: Wed Nov 21, 2018 11:30 am
by MarcR
An update:

MarcR
ApoE carrier status: 3/4
Polygenic Hazard Score: 88
AZ50: 86
Current age: 55
Cognitive status: (intact, SCI, MCI, early, mid, late): intact
Age of onset: N/A

MarcR father
ApoE carrier status: 3/4
Polygenic Hazard Score: 89
AZ50: 86
Current age: 78
Cognitive status: mid
Age of onset: 63

jkramer65
ApoE carrier status: 4/4
Polygenic Hazard Score: 100
AZ50: 80
Current age: 53
Cognitive status: intact
Age of onset: N/A

MyDestinyisfromGod
ApoE carrier status: 3/4
Polygenic Hazard Score: 93
AZ50: 86
Current age: 53
Cognitive status: intact
Age of onset: N/A

Plumster
ApoE carrier status: 3/4
Polygenic Hazard Score: 81
AZ50: 87
Current age: 49
Cognitive status: intact
Age of onset: N/A

Flyin66
ApoE carrier status: 4/4
Polygenic Hazard Score: 99
AZ50: 80
Current age: early 50s
Cognitive status: intact
Age of onset: N/A

Re: Polygenic info used to identify risk of AD

Posted: Wed Nov 21, 2018 11:57 am
by mike
So just looking at the pattern, if you are 4/4, your Hazard score goes to 99-100% with a 50% chance of having AD by 80 years old, where as 3/4's Hazard scores vary between 81 and 93 with 50% not until 86 years old. Does that mean that 3/4s have a better chance of changing their likelihood of getting AD than 4/4s based on lifestyle changes?

Re: Polygenic info used to identify risk of AD

Posted: Mon Dec 02, 2019 2:25 am
by MyDestinyisfromGod
I happened to see this encouraging news today about some things coming down the pipeline. But I also noticed that it said that everyone has a 50% chance of developing Alzheimer’s by age 85. I’m not sure it makes any difference in my thoughts about my chances, but it seemed I was a bit less unusual. I know that I could develop symptoms well before age 85 or 90. A 15% chance or whatever is still a chance. But it was an interesting short article.

https://www.health.harvard.edu/blog/a-c ... 9112718446

Re: Polygenic info used to identify risk of AD

Posted: Mon Dec 02, 2019 5:06 am
by Julie G
So just looking at the pattern, if you are 4/4, your Hazard score goes to 99-100% with a 50% chance of having AD by 80 years old, where as 3/4's Hazard scores vary between 81 and 93 with 50% not until 86 years old.
As a 4/4, it seems as though the test would be a waste of money.
Does that mean that 3/4s have a better chance of changing their likelihood of getting AD than 4/4s based on lifestyle changes?
3/4s certainly have a better chance of not developing AD, but this test doesn't address epigenetic influences for either group.

Re: Polygenic info used to identify risk of AD

Posted: Mon Dec 02, 2019 3:18 pm
by mike
Julie G wrote:3/4s certainly have a better chance of not developing AD, but this test doesn't address epigenetic influences for either group.
I was wondering since 3/4s have a broad Hazard range, while 4/4s do not, if that implied more variability among 3/4s and maybe more effect from changes.

Re: Polygenic info used to identify risk of AD

Posted: Fri Aug 14, 2020 10:16 am
by xingxu
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Re: Polygenic info used to identify risk of AD

Posted: Sat Aug 15, 2020 5:40 pm
by MyDestinyisfromGod
Thank you for all your research and for helping us to understand things a little better.

Re: Polygenic info used to identify risk of AD

Posted: Mon Dec 06, 2021 6:36 pm
by xingxu
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