High-fat diet leads to same intestinal inflammation as a virus

[Gilgamesh]

https://medicalxpress.com/news/2017-06-high-fat-diet-intestinal-inflammation-virus.html

Will have to read the study to see what kind of fat it was, of course (and whether there was any bodyweight change).

[Julie G]

From mice to men? From Harrison:

Rodent diet studies are limited in their generalizability. A slightly different way of thinking about this is that in mice, fat appears to be necessary to create a pro-inflammatory environment. In humans, sucrose appears to be necessary for a pro-inflammatory environment.

[apod]

Here's the "high fat" diet used in the study (Teklad, Harlan, catalog #TD88137): http://www.envigo.com/resources/data-sheets/88137.pdf

It's ~43% carb, and 42% fat. The carbs are primarily white sugar with a bit of corn starch. The fat comes from "anhydrous milkfat" with 1.5g of cholesterol per Kg of feed. They throw on racemix methionine, casein (I'm guessing one of the sketchier caseinate forms), then hit it with minerals, a synthetic "vitamin mix" (which is largely more corn starch), and extra calcium.

The title could also read "Caged animals fed crystalline sugar, genetically modified refined grain extracts, powdered anhydrous milk fat, and synthetic proteins while supplementing calcium and other metals leads to inflammation."

[Harrison]

From mice to men? From Harrison:

Rodent diet studies are limited in their generalizability. A slightly different way of thinking about this is that in mice, fat appears to be necessary to create a pro-inflammatory environment. In humans, sucrose appears to be necessary for a pro-inflammatory environment.

Another word of caution for this particular study (http://www.jlr.org/content/early/2017/06/13/jlr.M076554):

They used mice that are completely lacking the LDL receptor. This is of course not remotely natural, but does have a link to apoE. Specifically, too much apoE leads to more amyloid beta build-up, and activating the LDL receptor reverses this (https://www.ncbi.nlm.nih.gov/pubmed/20005821) .

I wouldn't dismiss this outright, but we need to understand if the treatment they used (ezetamibe + tomato peptide) are relevant in humans.

[apod]

From mice to men? From Harrison:

Rodent diet studies are limited in their generalizability. A slightly different way of thinking about this is that in mice, fat appears to be necessary to create a pro-inflammatory environment. In humans, sucrose appears to be necessary for a pro-inflammatory environment.

Another word of caution for this particular study (http://www.jlr.org/content/early/2017/06/13/jlr.M076554):

They used mice that are completely lacking the LDL receptor. This is of course not remotely natural, but does have a link to apoE. Specifically, too much apoE leads to more amyloid beta build-up, and activating the LDL receptor reverses this (https://www.ncbi.nlm.nih.gov/pubmed/20005821) .

I wouldn't dismiss this outright, but we need to understand if the treatment they used (ezetamibe + tomato peptide) are relevant in humans.

Semi-related, tomatidine is also a pretty new and intriguing tomato extract with effects on LDL:

You should be able to buy it soon: tomatidine, the anabolic in tomatoes: http://www.ergo-log.com/tomatidine-the- ... atoes.html

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway: https://www.ncbi.nlm.nih.gov/pubmed/28397803

Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase: https://www.ncbi.nlm.nih.gov/pubmed/22224814

[ru442]

You should be able to buy it soon: tomatidine, the anabolic in tomatoes: http://www.ergo-log.com/tomatidine-the- ... atoes.html

Looks like it is available from this company:

http://www.antaeuslabs.com/product/titan/

[Julie G]

Pretty sure pizza would work (E4 humor)

[ru442]

Pretty sure pizza would work (E4 humor)

LOL!.... snort!

[Gilgamesh]

apod, thanks for being far less lazy than I was this morning when I posted the link to the report on the study! The dietary constituents make it pretty clear that I can keep eating my mounds of nuts! (Or rather: that this study provides no evidence to make me stop.)

The tomato compound is nonetheless very intriguing. Will be following that research.

[Stavia]

The title could also read "Caged animals fed crystalline sugar, genetically modified refined grain extracts, powdered anhydrous milk fat, and synthetic proteins while supplementing calcium and other metals leads to inflammation."

love it!!



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