Nutritional & Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging / Alzheimer’s (2017)

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apod
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Nutritional & Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging / Alzheimer’s (2017)

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Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease (Frontiers in Aging Neuroscience)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461295/
Regarding nutritional approaches, a first step could be adopting, the earlier the better, a healthy eating lifestyle, as close as possible to the Mediterranean diet, in order to increase the intake of bioactive compounds and contribute to healthy aging. Considering the multifactorial nature of cognitive impairment in aging, especially in AD, it is evident that a multitarget-based approach is essential to address this complex condition (Bolognesi, 2013). Interestingly, this multitarget approach can be obtained through either pharmacological or nutritional strategies, however the combined use of both approaches in order to obtain a synergistic effect could be even more effective most probably as a preventive AD/cognitive aging strategy and perhaps also as a therapeutic approach.
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