The lack of DNA damage at low doses suggested that low levels of curcumin does not induce DNA damage and may play an antioxidant role in carcinogenesis. But at high doses, we found that curcumin imposed oxidative stress and damaged DNA. These data reinforce the hypothesis that curcumin plays a conflicting dual role in carcinogenesis. Also, the extensive mitochondrial DNA damage might be an initial event triggering curcumin-induced cell death.
Cited in 20 studies but I don't have time to delve.
I've been taking curcumin a long time, first 400 mg and along the way switched to 800 mg.
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Julie it looks like a March 2017 paper titled The Essential Medicinal Chemistry of Curcumin cited your paper among many others. Oddly, that review said no double-blind, placebo-controlled trial in people 'has been successful'. They are probably using fairly strict standards. This newer paper might be worth a dive because it looks like it approaches curcumin from a different angle. Not having read it, I wonder if curcumin is neurotrophic and if that accounts for cognitive benefits but also makes it, like other growth factors, pro-cancer at higher doses, although at just a brief glance this appears much more technical.
ApoE 3/4 > Thanks in advance for any responses made to my posts.
I'm a functional doctor and find that patients who are homozygous for the CBS gene can feel quite 'toxic' ( foggy head/ nausea/ headache etc) when they take too many sulphur based nutrients and food. Basically, the gene speeds up the breakdown of sulphur nutrients ( like turmeric) and ammonia is a byproduct. Not only is ammonia toxic but the body diverts BH4 to neutralise it. It's a bit complex - when there is insufficient BH4, more free radicals are produced which causes inflammmation.
Drserene wrote:I'm a functional doctor and find that patients who are homozygous for the CBS gene can feel quite 'toxic' ( foggy head/ nausea/ headache etc) when they take too many sulphur based nutrients and food. Basically, the gene speeds up the breakdown of sulphur nutrients ( like turmeric) and ammonia is a byproduct. Not only is ammonia toxic but the body diverts BH4 to neutralise it. It's a bit complex - when there is insufficient BH4, more free radicals are produced which causes inflammmation.
thanks DrSerene. What in your opinion would be a generally tolerated dose?
It's the sum total of all sulphur ingested and the CBS inheritance, so it's difficult to quantify as everyone is different.
Some people take a bunch of kale/ spinach in their daily smoothies, cauliflower rice and eat a lot of meat . Just a small amount of turmeric will tip them into a inflamed state if they are homozygous for the cbs gene. You can get your urinary sulphates tested (http://www.westlab.com.au/advanced_sear ... 00&x=0&y=0 ) - Australian site. If it's about 400mg to 800 mg/L, you can probably tolerate 500 mg turmeric.
. I'm using a lot, partially based on this 
