It appears that this is the appropriate forum to alert the group to the recent findings that Tramiprosate has been shown to change the downward trajectory of cognitive decline but only in those who carry APOE4.
http://www.jpreventionalzheimer.com/200 ... ffect.html
Tramiprosate
Re: Tramiprosate
Interesting. For those who don't know, "Tramiprosate inhibits aggregation of amyloid monomers into soluble oligomeric species that cause synaptic toxicity."
According to Table 1 about 95% of participants were on acetylcholinesterase inhibitors and mid-40% on memantine (targets the glutamatergic system). Wonder if E4s not on these drugs would have had a similar outcome - perhaps there could be an additive effect for E4s with the other drugs?
According to Table 1 about 95% of participants were on acetylcholinesterase inhibitors and mid-40% on memantine (targets the glutamatergic system). Wonder if E4s not on these drugs would have had a similar outcome - perhaps there could be an additive effect for E4s with the other drugs?
Re: Tramiprosate
Hey SusanJ,
Regarding your question on additive effects, it would be hard to test. So many AD patients are put on the ACHeI's and memantine, that it's hard to find patients who aren't on the drugs. Still, this is an interesting result, and hopefully some good news for us.
I'm hoping Alzheon can get some funding and move forward on a phase III in e4/e4's.
Dyver
Regarding your question on additive effects, it would be hard to test. So many AD patients are put on the ACHeI's and memantine, that it's hard to find patients who aren't on the drugs. Still, this is an interesting result, and hopefully some good news for us.
I'm hoping Alzheon can get some funding and move forward on a phase III in e4/e4's.
Dyver
