Genesis of the 1500 IQ Humanoids

[slacker]

I am not sure that a higher IQ would also result in more compassion and empathy. "Smart" doesn't always equate with "emotional intelligence." Einstein may not have been wealthy, but he also had a reputation of being a bit neglectful and cruel to his family...

[J11]

Slacker, yes this is true that there is a confounding influence caused by autistic type behavior that can occur at higher levels of intelligence. It is not clear to me to what extent selecting for IQ would also necessarily also select for autism. The research might
have found that these are in fact separable.

[J11]

This recent wave of research has made me rethink my perception of what we currently regard as high intelligence. Until now I had no notion of how one might genetically control IQ. It seemed so magical that there were people with varying levels of intelligence.
How could this have ever happened? What genetic features could explain such an outcome?

The answer has only emerged over the last few years: variation of human intelligence result from differential inheritance of tens of thousands of SNPs -- most of which are common. It is not as magical as it seemed at first glance.

As a result of the extreme polygenicity, no one person or group has ever shown anything close to an extreme phenotype.
High IQ Asian nations have demonstrated national IQs of at most half a standard deviation above European standards.
With regression to the mean, IQs far above average would through generations tend to more typical scores.

While the understanding of how high intelligence can be created has removed some of the magic and wonder, a possible
future world filled with extremely intelligent people still has a sense of awe. I can hardly wait to see what will happen.
The technology is so easy; simply choosing 1 in 10 embryos gives 1 SD! 1 SD now defines human experience. What happens
when we charge through this barrier and beyond? Waiting for the arrival of the first generation of such genetically enhanced
humans over the next few months will be so exciting!

[J11]

We have let this thread drift for the last two months.
Two months is an eternity when dealing with a fast developing technology.
As soon as we hit the exponential elbow of the curve, we will need to sprint even to keep even.

Due to the nature of the scientific publishing model, this is where the state of the art was 6 months ago.
PMID: 29326435

It is already expected that the research needed to unlock human intelligence has been in the research
process for many months.

There can be almost no doubt that we are now at the very moment before human civilization is massively disrupted. Being able to accurately phenotype babies, children, students, family, dates, adults, workers, husbands, wives, friends, neighbors, prospective homebuyers, citizens, suspected criminals, acquaintances by simply genotyping has such overwhelmingly profound consequences for how we will soon live our lives that it is beyond the scope of a mere thread post. The suggestion that this will somehow blow over or will not occur until the distant future does not correspond to the facts as they are now known.

A wide range of human traits are now unlocking. With such far ranging insights that will be available into people's unique biologies, a great deal of contemplation will be required to interpret it all. How will a person of very high genetic IQ will be judged in this new genetic market who might also have a high risk exposure for depressive illness? It will likely soon be understood that with the dozens of traits that are now being studied, it will be essentially impossible to have anything close to what might be thought of as an ideal mix.

So, lesson 1 of this new genetic age will almost certainly be that we are all only human which is somewhat reassuring.

[J11]

Human IQ genome unlocked today.
Overwhelmingly profound significance.

Note to self: Begin intensive psychotherapy to try to cope with this.

[J11]

This is a monumental moment for humanity.
The below SNPs provide one of the best glimpses into the human mind that we have ever had.

What you will notice is that the pluses and the minuses in the betas are almost perfectly balanced out.
So there is a massive tug of war going on and the result for most people is about even.
The sum of all the positives alleles is 18.5 SD and of all the negative alleles is -17 SD.
So if someone hit all the positives and no negatives, one would have +37 SD of EA.
The world has never seen a person with +37 SD of EA using these 3000 SNPs in a polygenic score.
It is not even clear whether a person has ever had a polygenic score over 1.
The range reported using existing genetic databases is -0.3 - 0.7.

These are the genome significant SNPs for Educational Attainment that have just been found in
a 1 million person GWAS that are also on 23andme's v3 chip. They found about 3000 genome wide significant
SNPs; 578 are on 23andme chip. Some of the other 2500 might have proxies, so their contribution could also assessed.
There are thought to be 20,000 or more of these SNPs, so this is only a step forward on the research path. However,
the SNPs that have been reported are the large effect SNPs. many of the remaining could have very very small effect
sizes. In a first run through, these SNPs are already predicting real world outcomes. The reported correlation across populations
0.80. The full results have not been reported yet, though as a very rough guess these SNPs might explain 1/4-1/3 of the variance in
EA.

The profound implications of this are not related to what scores people might attain today with these SNPs, but the potential for genetically selecting the next generation for the optimal combination. On a first run through with the numbers we can call it
now as 50-100 SD of EA on the table (1500 IQ?). So this is already truly profound and it is still ramping up. To move this across the line and have complete genetic information of IQ and EA is now more a question of how society will cope with this than the
any technological obstacles.

Educational Attainment is moderately correlated with IQ. Some might ask what the point of estimating something with only moderate accuracy when it would be so much easier and completely accurate to check back on previous transcripts. Hmm, that is a good question. And the answer is is that some of these SNPs will be able to point to profound insights into how the brain works.

One fairly large uncertainty is what the A1 and A2 mean. It is still somewhat of a mystery to me.
The A1 and A2 do not seem to link up to the betas or the allele frequencies on dbsnp.
Will need to see what the upcoming article has to say.

A little program should be enough to include your 23andme genotypes into a spreadsheet with the results below.

rsnum chr pos A1 A2 EAF beta se p-value
rs1906252 6 98550289 A C 0.5034 0.021 0.001 8.86E-57
rs2526388 3 50174886 T C 0.716 -0.021 0.002 6.14E-45
rs17304079 3 50085153 A G 0.7058 0.021 0.002 3.22E-42
rs34316 5 88015545 A C 0.5799 0.018 0.001 4.06E-38
rs11171739 12 56470625 T C 0.5731 -0.017 0.001 3.26E-37
rs11588857 1 204587047 A G 0.7721 0.02 0.002 2.13E-34
rs749694 10 103519784 A G 0.4609 0.016 0.001 7.94E-34
rs586339 1 44137257 A C 0.716 0.018 0.002 1.44E-33
rs176218 14 29600506 T G 0.7993 0.02 0.002 7.50E-33
rs7849487 9 1757274 T G 0.3844 -0.017 0.001 8.71E-33
rs10189857 2 60713235 A G 0.4184 0.016 0.001 3.78E-32
rs4919624 10 104021085 A G 0.1922 0.019 0.002 7.03E-31
rs10215082 7 92657985 A G 0.4388 -0.015 0.001 1.28E-28
rs11720523 3 71545170 A C 0.5544 0.015 0.001 2.46E-28
rs6557171 6 152234593 T C 0.7245 -0.015 0.001 1.26E-27
rs12069733 1 43941508 A G 0.3639 -0.015 0.001 1.82E-27
rs12741781 1 243428152 T G 0.6548 0.015 0.001 3.14E-27
rs363096 4 3180021 T C 0.5748 -0.014 0.001 1.73E-26
rs7683416 4 106152984 T C 0.4048 0.014 0.001 2.35E-25
rs11665242 18 50907127 A G 0.5884 0.014 0.001 2.79E-25
rs1043595 7 128410012 A G 0.7143 0.015 0.001 5.36E-25
rs11157930 14 23403171 T G 0.619 -0.014 0.001 1.86E-24
rs3101338 1 72750353 A C 0.8248 0.017 0.002 2.24E-24
rs4500960 2 162818621 T C 0.5306 -0.013 0.001 7.23E-23
rs1054442 12 49389320 A C 0.3282 -0.014 0.001 7.65E-23
rs4490539 5 60685757 A G 0.3129 0.014 0.001 9.34E-23
rs2188177 7 92659160 T C 0.5204 0.013 0.001 1.29E-22
rs10810099 9 14161927 A G 0.2823 -0.015 0.001 1.42E-22
rs12506221 4 67899235 T G 0.5442 -0.013 0.001 3.41E-22
rs13429247 2 10960529 A G 0.7007 -0.015 0.002 4.15E-22
rs2725371 8 30854033 A G 0.2891 -0.014 0.001 4.72E-22
rs2309723 2 100346964 T C 0.4796 -0.013 0.001 8.20E-22
rs2838006 21 42653567 T C 0.6378 0.013 0.001 1.28E-21
rs1964927 21 42653237 A G 0.6378 0.013 0.001 1.34E-21
rs750472 8 145701453 A C 0.5 -0.013 0.001 1.41E-21
rs2179152 6 26325888 T C 0.6429 -0.013 0.001 1.58E-21
rs975303 6 19028788 A G 0.1429 -0.017 0.002 1.78E-21
rs7323027 13 58693790 A G 0.5612 0.013 0.001 4.06E-21
rs2837992 21 42620520 T C 0.3759 0.013 0.001 4.34E-21
rs6065080 20 59832791 T C 0.6531 -0.013 0.001 8.38E-21
rs178203 14 26959322 T C 0.2704 0.014 0.002 9.51E-21
rs1245214 14 26935221 A G 0.2636 -0.014 0.002 1.47E-20
rs2630765 5 176876825 T C 0.5221 0.012 0.001 1.64E-20
rs613872 18 53210302 T G 0.1718 -0.016 0.002 2.42E-20
rs13107325 4 103188709 T C 0.90986 -0.024 0.003 2.46E-20
rs728054 7 137072364 A G 0.6378 -0.013 0.001 2.98E-20
rs17782474 2 100265936 A G 0.90816 0.02 0.002 4.85E-20
rs790647 10 106776484 A C 0.7653 -0.015 0.002 5.09E-20
rs9616906 22 51104680 A G 0.5765 0.012 0.001 1.21E-19
rs6666119 1 110040310 A G 0.7024 -0.013 0.001 2.07E-19
rs2293445 12 49398862 A G 0.6633 0.012 0.001 2.09E-19
rs4726070 7 151328218 A G 0.3793 0.012 0.001 2.09E-19
rs362307 4 3241845 T C 0.93707 -0.023 0.003 2.42E-19
rs11772444 7 133453874 A G 0.199 -0.015 0.002 2.73E-19
rs717996 12 84133820 T C 0.6207 -0.012 0.001 3.02E-19
rs17502934 2 50994255 T G 0.1293 -0.017 0.002 3.44E-19
rs6493265 15 47513253 T C 0.6105 -0.012 0.001 3.68E-19
rs2237318 7 24769278 T C 0.3163 0.013 0.001 5.55E-19
rs10854884 22 51101899 A C 0.5731 0.012 0.001 5.90E-19
rs10496091 2 61482261 A G 0.7109 -0.013 0.001 6.42E-19
rs1362910 8 30856464 A G 0.6088 -0.012 0.001 7.06E-19
rs1144593 1 110030945 A G 0.2993 -0.013 0.001 9.72E-19
rs10875914 12 49422094 A G 0.3554 -0.012 0.001 1.16E-18
rs635754 1 96484940 A G 0.5306 0.012 0.001 1.16E-18
rs7977614 12 110115286 A G 0.3078 -0.013 0.002 1.27E-18
rs12957463 18 37412228 A G 0.8129 0.015 0.002 1.75E-18
rs7233920 18 37416318 A G 0.216 -0.014 0.002 1.98E-18
rs10783299 12 49390677 T C 0.3401 -0.012 0.001 2.40E-18
rs2570497 2 104441546 T C 0.3265 -0.012 0.001 2.49E-18
rs3794621 16 1247606 A G 0.5935 -0.012 0.001 2.70E-18
rs2726513 4 106217358 T G 0.5969 -0.012 0.001 2.84E-18
rs8044363 16 1250559 T C 0.5935 0.012 0.001 3.31E-18
rs9643888 8 42352007 T C 0.6259 0.012 0.001 3.41E-18
rs6704768 2 233592501 A G 0.4796 -0.012 0.001 3.79E-18
rs1569092 1 74858724 A G 0.182 0.016 0.002 4.43E-18
rs7122044 11 72462634 A G 0.2092 0.013 0.002 6.14E-18
rs6569077 6 98212409 T C 0.5765 0.012 0.001 7.25E-18
rs4984541 15 96911139 A G 0.7585 -0.014 0.002 7.50E-18
rs966221 5 59502520 A G 0.3929 -0.012 0.001 7.51E-18
rs9655780 7 104667334 A G 0.1718 -0.015 0.002 8.25E-18
rs12289262 11 12894758 T C 0.2721 -0.013 0.002 8.34E-18
rs12646523 4 170944698 T C 0.7381 -0.013 0.002 8.46E-18
rs4131987 7 3380895 T C 0.5102 -0.011 0.001 2.55E-17
rs6954 1 43916642 T C 0.4116 -0.011 0.001 5.64E-17
rs7236339 18 77579773 A G 0.1956 -0.013 0.002 1.17E-16
rs2073526 6 26374658 A G 0.3929 0.011 0.001 1.95E-16
rs13422673 2 155474355 T C 0.5153 -0.011 0.001 1.98E-16
rs978807 18 36898459 A G 0.7738 0.014 0.002 2.90E-16
rs3895736 3 48658467 A C 0.1599 0.014 0.002 3.18E-16
rs17669337 5 92187932 T C 0.5765 -0.011 0.001 3.59E-16
rs12342546 9 126329270 A G 0.7415 -0.013 0.002 3.61E-16
rs8024 1 201845575 A C 0.3112 -0.012 0.001 3.69E-16
rs485929 1 74678285 A G 0.6241 -0.011 0.001 4.26E-16
rs350281 16 12231739 T G 0.7313 -0.012 0.001 4.70E-16
rs767943 6 23446691 A C 0.6888 -0.012 0.001 5.17E-16
rs7254263 19 30741257 T C 0.2653 -0.012 0.001 6.31E-16
rs863006 1 159177748 A G 0.3912 -0.011 0.001 6.83E-16
rs1517810 1 201850057 T C 0.6871 0.011 0.001 8.11E-16
rs11871429 17 42920929 A G 0.7959 0.013 0.002 8.96E-16
rs1866823 8 57436577 A G 0.551 0.011 0.001 1.13E-15
rs3935685 15 78034268 T C 0.449 -0.011 0.001 1.31E-15
rs9267677 6 31892641 T C 0.8878 0.018 0.002 1.36E-15
rs6798507 3 71547039 A G 0.352 0.011 0.001 1.76E-15
rs12602286 17 19236954 T G 0.8861 0.016 0.002 1.76E-15
rs7931563 11 61446425 T G 0.3912 -0.011 0.001 1.98E-15
rs10798888 1 32199099 T G 0.1446 -0.014 0.002 1.99E-15
rs4800201 18 22636415 A G 0.7245 -0.012 0.001 2.11E-15
rs17565975 11 111586950 A G 0.5306 -0.011 0.001 2.16E-15
rs9789595 2 107539301 T C 0.3537 0.011 0.001 3.03E-15
rs12170452 22 40019773 A G 0.5629 0.011 0.001 3.15E-15
rs11599236 10 106454672 T C 0.5748 -0.011 0.001 4.14E-15
rs2050256 1 32204683 A G 0.8605 0.014 0.002 4.72E-15
rs9853928 3 103295384 T C 0.2109 -0.013 0.002 6.99E-15
rs7724655 5 107032708 T G 0.4677 0.01 0.001 7.31E-15
rs10805383 5 63034606 A G 0.4745 -0.01 0.001 1.01E-14
rs2256965 6 31555130 A G 0.5425 0.011 0.001 1.10E-14
rs3896224 10 106467853 A G 0.4269 -0.01 0.001 1.13E-14
rs1120924 4 5228939 T C 0.699 0.011 0.001 1.30E-14
rs7988959 13 99104004 T C 0.2959 -0.011 0.001 1.31E-14
rs1167827 7 75163169 A G 0.5663 0.01 0.001 1.38E-14
rs6449674 5 62995938 T C 0.5289 0.01 0.001 1.56E-14
rs17641524 1 197704717 T C 0.182 -0.013 0.002 1.61E-14
rs12503522 4 94543233 T C 0.7517 -0.011 0.001 1.90E-14
rs9569233 13 55786955 A C 0.6429 0.011 0.001 2.17E-14
rs9886703 9 82246351 A T 0.1701 -0.014 0.002 2.20E-14
rs2014830 3 50172397 T C 0.6956 0.011 0.001 2.33E-14
rs13224108 7 126595060 T G 0.7993 0.012 0.002 2.41E-14
rs7560871 2 145616899 A G 0.05952 -0.019 0.003 2.62E-14
rs9386110 6 145626208 T C 0.8929 -0.016 0.002 2.85E-14
rs1329044 9 23747791 T C 0.1497 0.013 0.002 3.20E-14
rs3809634 16 53538157 A G 0.665 -0.011 0.001 3.51E-14
rs17556717 13 92028253 A G 0.1156 -0.018 0.002 4.18E-14
rs11100237 4 160477041 A G 0.4303 -0.01 0.001 4.29E-14
rs2490395 1 243458922 A G 0.5391 -0.01 0.001 4.47E-14
rs10510388 3 8257574 A C 0.3452 -0.01 0.001 4.58E-14
rs7038525 9 23772277 T C 0.8469 -0.013 0.002 4.79E-14
rs730384 14 74889870 A G 0.5442 0.01 0.001 5.01E-14
rs10448005 8 135427757 T C 0.1003 -0.015 0.002 5.76E-14
rs6994287 8 9340932 A G 0.5799 0.01 0.001 6.02E-14
rs2515919 6 31564167 A G 0.3759 0.01 0.001 6.40E-14
rs981230 5 59039858 T C 0.5255 0.01 0.001 7.07E-14
rs12799722 11 95834689 A G 0.6207 0.01 0.001 1.10E-13
rs1462163 2 164333146 T C 0.5578 -0.01 0.001 1.11E-13
rs1060709 13 31903834 T G 0.2738 -0.011 0.002 1.12E-13
rs16931322 9 14078878 A G 0.06122 -0.019 0.003 1.37E-13
rs17604349 16 72210865 A G 0.8333 0.013 0.002 1.39E-13
rs2216144 12 97666478 T C 0.4558 0.01 0.001 1.53E-13
rs9986272 5 88120326 T C 0.07313 0.019 0.003 1.61E-13
rs356999 2 60811584 A G 0.3605 -0.01 0.001 1.76E-13
rs3735478 7 44800176 T G 0.2857 0.011 0.001 2.27E-13
rs2470961 7 104435213 A G 0.5595 -0.01 0.001 2.36E-13
rs1015438 16 51177517 A G 0.2143 -0.012 0.002 2.68E-13
rs1117152 12 15438032 T G 0.3299 0.011 0.001 2.84E-13
rs10232276 7 126583521 T C 0.2228 0.012 0.002 3.21E-13
rs9267658 6 31845985 T C 0.1156 0.014 0.002 3.39E-13
rs6539284 12 79592680 T C 0.5544 -0.01 0.001 3.43E-13
rs9373363 6 143150043 A G 0.7704 -0.011 0.002 3.60E-13
rs6956293 7 133130178 T C 0.7551 0.012 0.002 3.77E-13
rs1013982 16 72450482 A G 0.6667 -0.01 0.001 3.90E-13
rs721579 17 43370481 T C 0.2466 -0.011 0.002 3.91E-13
rs8019932 14 30606426 T G 0.7109 -0.01 0.001 4.25E-13
rs981883 5 57107989 A G 0.5918 0.01 0.001 4.44E-13
rs10937240 3 185802823 T C 0.1956 -0.012 0.002 4.61E-13
rs1805008 16 89986144 T C 0.93878 0.017 0.002 4.82E-13
rs4659520 1 235575321 T C 0.4558 0.01 0.001 4.95E-13
rs13133213 4 15646794 A G 0.5204 0.01 0.001 5.09E-13
rs10773208 12 122970156 T C 0.2619 -0.011 0.002 5.49E-13
rs1076485 11 116772441 T C 0.8622 0.014 0.002 5.94E-13
rs4674916 2 225365635 A C 0.6786 0.01 0.001 7.24E-13
rs2283076 7 126478190 A G 0.7857 0.011 0.002 7.35E-13
rs7625428 3 56570907 T C 0.4014 0.01 0.001 7.42E-13
rs2447097 17 2278064 T G 0.5306 0.01 0.001 7.74E-13
rs10734924 12 123018894 T G 0.733 -0.011 0.002 7.87E-13
rs7724301 5 57114080 T C 0.7466 -0.011 0.002 8.19E-13
rs4358081 2 29100642 A C 0.449 -0.01 0.001 9.12E-13
rs6534338 4 123026869 T C 0.3248 0.01 0.001 1.06E-12
rs9267576 6 31812038 T G 0.1156 0.013 0.002 1.26E-12
rs7803932 7 70203673 A G 0.1565 0.013 0.002 1.28E-12
rs17048879 3 8275541 T C 0.6327 -0.01 0.001 1.31E-12
rs12453682 17 37770005 T C 0.6837 0.01 0.001 1.34E-12
rs482787 10 99767024 T C 0.6633 0.01 0.001 1.46E-12
rs9957365 18 22652817 A G 0.6786 0.01 0.001 1.53E-12
rs12162090 16 62081034 A G 0.165 -0.013 0.002 1.64E-12
rs11652522 17 43055579 A C 0.91497 -0.015 0.002 1.74E-12
rs7597126 2 215009358 T C 0.5221 -0.009 0.001 1.88E-12
rs312927 19 3274770 A G 0.8878 -0.015 0.002 1.94E-12
rs4678090 3 123880441 T C 0.6871 -0.01 0.001 1.95E-12
rs2160514 12 16756508 A C 0.4184 -0.009 0.001 1.95E-12
rs4589766 2 125940717 A G 0.04082 0.022 0.003 1.97E-12
rs4328757 3 36938180 T C 0.6514 0.01 0.001 2.31E-12
rs1507010 16 7657373 A G 0.4949 -0.009 0.001 2.67E-12
rs3785229 16 7670999 A G 0.5221 -0.009 0.001 2.70E-12
rs6541349 1 93787867 T C 0.8537 0.013 0.002 2.78E-12
rs9545395 13 36370970 T C 0.8537 0.014 0.002 3.05E-12
rs12151248 19 13212025 T C 0.8895 -0.015 0.002 3.05E-12
rs9527905 13 59403033 A G 0.5986 -0.009 0.001 3.34E-12
rs4744250 9 96271752 A G 0.352 0.01 0.001 4.13E-12
rs11623285 14 24557642 T G 0.1207 -0.014 0.002 4.68E-12
rs9771228 7 32322496 T C 0.6735 0.01 0.001 4.99E-12
rs12670376 7 48823154 A G 0.5306 0.009 0.001 5.05E-12
rs7500549 16 78243384 T C 0.5408 -0.009 0.001 5.23E-12
rs9927842 16 15153717 T C 0.8452 -0.013 0.002 5.29E-12
rs252991 5 106767346 A G 0.6003 0.009 0.001 5.34E-12
rs12789313 11 25058937 T C 0.5323 0.009 0.001 5.82E-12
rs11704277 22 38826799 T C 0.92517 0.015 0.002 6.50E-12
rs4851263 2 100801867 A G 0.8878 -0.015 0.002 6.83E-12
rs1329125 1 234740880 T C 0.6786 -0.01 0.001 7.34E-12
rs4941735 13 31641248 T C 0.568 0.009 0.001 7.60E-12
rs4780563 16 14975292 A G 0.8282 -0.013 0.002 7.81E-12
rs1616727 9 111697427 A G 0.5731 0.009 0.001 7.97E-12
rs1050847 16 87443734 T C 0.415 0.009 0.001 8.15E-12
rs1041073 13 31891746 A G 0.2415 -0.011 0.002 8.48E-12
rs1106090 2 58068741 A G 0.6259 0.009 0.001 8.98E-12
rs1991110 2 161942911 T C 0.1105 -0.014 0.002 9.07E-12
rs12891042 14 34018986 T C 0.568 0.009 0.001 9.08E-12
rs4557224 4 30796107 T C 0.5187 -0.009 0.001 9.24E-12
rs2336721 3 53028375 T C 0.6395 0.01 0.001 9.46E-12
rs10042828 5 88308777 A G 0.1293 -0.014 0.002 9.55E-12
rs10750539 11 133548873 A G 0.3367 -0.009 0.001 1.00E-11
rs1171044 1 190385304 T C 0.2194 -0.011 0.002 1.01E-11
rs2210054 14 34022139 A G 0.5697 0.009 0.001 1.03E-11
rs628594 1 110760444 A G 0.6259 0.009 0.001 1.05E-11
rs12519073 5 136776762 T C 0.7619 -0.011 0.002 1.05E-11
rs12912465 15 77309459 T C 0.7415 -0.01 0.002 1.06E-11
rs6736992 2 226538647 A G 0.7041 -0.01 0.001 1.09E-11
rs4425734 8 87277575 A G 0.5544 0.009 0.001 1.12E-11
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[DeterminedActivist]

This is a monumental moment for humanity.
The below SNPs provide one of the best glimpses into the human mind that we have ever had.

What you will notice is that the pluses and the minuses in the betas are almost perfectly balanced out.
So there is a massive tug of war going on and the result for most people is about even.
The sum of all the positives alleles is 18.5 SD and of all the negative alleles is -17 SD.
So if someone hit all the positives and no negatives, one would have +37 SD of EA.
The world has never seen a person with +37 SD of EA using these 3000 SNPs in a polygenic score.
It is not even clear whether a person has ever had a polygenic score over 1.
The range reported using existing genetic databases is -0.3 - 0.7.

Hi, any update on this research? I tried to work out possible z-score via your less-SNP-rich post and I got a negative result. I had a -20 something z-score. I am not particularly good at statistics, but you mentioned that z-score of 300 means one standard deviation of IQ in either direction. I scored negative -20 but my IQ is somewhere between 120-125 due to me finishing computer science at University of Cambridge and having scored high in end of school exams. I spent an hour data wrangling with Pandas and with my Ancestry DNA chip, joining your SNPs list with either concrete item in DNA file or joining proxy for a missing SNP on concrete item in DNA file.

All I can say is it was interesting but the z-score hypothesis might be bunk for how these small parts of genome provide a commulative effect. Or it might be correct but we just have too few SNPs to get the whole picture. I watched what Stephen Hsu researched about X Std.dv. humans but it looks too simplistic on this tiny model.

What z-score did you get because you clearly are an intelligent person.

[J11]

DeterminedActivist, thank you very much for replying and reactivating this thread.

IQ uplift is a monumentally important topic and yet I have encountered pervasive reluctance
to engage in discussing it online. Given that people tend to converse about everything; except
what is of supreme importance, this silence indicates to me extreme uncertainty and anxiety
about how we will cope with the profound disruption to human civilization that the genetic
selection which is currently occurring will eventually cause.

There are no easy answers to the problems that we will face from genetic enhancement of intelligence
(and likely a range of other features of human psychology etc.). There is no manual to consult. The deliberate
genetic engineering of human intelligence with the sophisticated tools now at our disposal has never
occurred before. Environmental challenges have on occasion lead to enhancement gains of perhaps 1 IQ
point in human cognitive ability over a millennium. Such enhancement meaningfully altered human behavior.
How are we expected to cope with a Cognitive Singularity Event which will create essentially infinite human
(and artificial) cognitive ability within this century? I do not envy the grownups who are in charge: All they
can say is "Don't!". This is good advice, though likely of questionable real world effect. There is no obvious
optimal strategy: Ignoring cognitive enhancement and hoping it will just blow over would create a range of
consequences perhaps as disruptive as accepting reality.


The research has slowed down somewhat of late, though I expect that in the not too distant future
yet more results will move us even closer to Singularity. The below research reports 255 IQ points
locked into haplotypes along with 30 IQ points of causal SNPs. We already have the genetic knowledge
that would overcome existing cognitive differences in human populations. Psychometric discussions
predicated on presumed enduring differences between human populations should now be recognized as
pseudo-scientific.

Below research also reports that 2.5 IQ point genetic enhancement is currently achievable with very
minimal and affordable existing technology. These results should concern us greatly.

Genetic enhancement of human intelligence is now possible.

I suspect that the above headline has not reached mass consciousness, though it is vitally important
that it does. I have already encountered a few people who really did not seem to want to process this
idea. I am sure that they love their children and their family with a passion, however neglecting to
integrate this idea into how they understand reality will cause more harm to their family than anything
else that I think reasonably applies. Ideas matter. The people with the least cognitive ability to cope
with the consequences of cognitive upgrade will more than likely be the same people who will
turn a blessing into a curse. In a world of cognitive enhancement, unenhanced children
would have no future.

Under slightly different technological assumptions the 2.5 IQ points of cognitive enhancement noted
above could morph into 30 points. There is no possible way that humanity could realistically cope with a 2 SD
enhancement of average cognitive ability in a single generation.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393768/
https://www.biorxiv.org/content/10.1101/626846v1

At this magical time of year as we await the arrival of a new year,
consider the approach of a high intelligence, genetically enhanced
humanoid species that will fill our lives with wonder and enchantment.
Hopefully a dialogue can begin about the wide ranging potential such
enhancement could bring to us. Enhanced intelligence is not a peripheral
concern for this forum: A few 500 IQ humanoids would likely be able to
rapidly cure Alzheimer's and more than likely all other human problems.

Best Wishes to everyone for the festive season and prayers that the changes
that are occurring will be a blessing for humanity.

[J11]

DeterminedActivist, thank you for your interest in genetic uplift.
It needs to be discussed more, though it hasn't been.

This is the most powerful idea that I have ever encountered in my life.
It is simply shocking.

My perception is that there has been a concerted and deliberate effort to suppress this idea from wider discussion.
This idea cannot be scientifically disputed.
Those who in any way dismiss the legitimacy of this idea are simply wrong.
There has largely been a complete absence in denying the basic premise because it cannot be rebutted.
The more glaring tactic has been to simply ignore it.

Yet, as this highly psychologically aware world is all too familiar, denial is not a mature response to ideas
that we might feel challenging. Denying reality is in fact often a dangerous strategy that merely intensifies
disruptions that will occur inevitably. We need to stop denying reality, accept it, and start an exciting adventure
to Cognitive Singularity. If we don't, then the potential IQ uplift could be vertical. There is already 255 IQ points of
haplotype uplift and 30 IQ points of causal uplift on the table. Doesn't this make you afraid? Are you smart enough to
understand how devastating that would be for humanity? OK, let's wait 5 years and look at 1,000 points of haplotype
IQ and 150 causal uplift. Scared yet? I would be terrified! Would you really want to have 10 SD lower intelligence
than the next generation? Nobody currently on this planet would have any job other than a make work day care for adults job.
Doing nothing is not an effective strategy. The longer that we deny reality, the more disruptive cognitive uplift will be.
Accepting reality will give us at least a small chance to have some amount of control over what will happen.


I think back to R.A. Fisher in 1919 when he was working through complex aspects of the mathematics of genetics and this highly
pertinent fact that humans could have IQs in excess of 1000 was a mere trifle, a footnote to the intricate calculations he was performing, and he overlooked it. His paper earned him a Master's degree. Mentioning that humans could have mega-intelligence would have been worth at least a Nobel. Think how history would have unfolded differently. Knowing that super-humans are on the way changes everything. It is the counterfactual that would have transformed modern history.

The change that should have happened then should happen now.
Profound genius humanoids with different dimensions of intellectual potential are on the way. Get ready!
Time to brush your hair, polish your shoes, add some extra starch in your collar and above all pray.
We need to be better people and we need to be better people fast.

The entire course of 20th Century history would have shifted with even the vague idea of super-genius humans.
It would (will) force us to be smarter, to be more moral and more kind.
All of Humanity is clearly vastly inadequate in comparison to what we now know is scientifically possible.

It should now be obvious that Alzheimer's research has not pursued the optimal path. Dr. Alzheimer himself did not believe that amyloid was causal for AD, he thought it was tau. He was right. Why have we been on the wrong path for over a hundred years. The Alzheimer's super-geniuses that are on the way can help us answer this question.


All humans have the inherent genetic potential to create 200 IQ children.
Yet, it is locked away in chromosomes and haplotypes that make it somewhat difficult to access.
Technology that has already been widely developed will allow us to access this potential.

The idea that the elite will be able to monopolize this is almost surely incorrect.
It would be right up there with people who wanted the internet all for themselves:

Mine! Mine! Mine! All Mine!

It is pitiful outdated thinking.

In a networked economy, value can only be created through strengthening the network.
To prove this, think back to the early days of the internet when there was a sparse network.
The network was sparse and it was an impoverished environment.

Those who want poverty all for yourself can have it; it's all theirs.

I remember back then and you couldn't pay me to spend time on computer networks.
Nobody mentioned Alzheimer's: now here we are and we can talk about what matters to us 24/7.

Same with genetics.
Genetic knowledge is a network.
My interests (and that of everyone else) are directly related to growing the network.
If we can genotype and soon sequence 100 million people, then finally the entire human genome
would completely unlock. We would fully understand intelligence, Alzheimer's: we would understand
everything.

IQ uplift is also a network.
Those who want it all: Mine! Mine! Mine! All Mine!
Will have nothing.

They will live in our impoverished world.
The logic will become increasingly obvious as humanity becomes smarter and smarter.
Life will start getting better and better and at a certain point the relative worth types will simply
give up. Who wants to be a ruler of a world of poverty and misery? Who wants to be relatively
wealthy in a world of want? This is a simple IQ test question. Those who can't figure it out should not
be put in a position of authority.

The potential wealth creation of a world of 1000 IQ would be almost infinite.
Those with such massive intelligence would produce annual wealth well in excess of
$ e+30. There would be profound levels of potential wealth generation.

An inevitable part of IQ uplift will be that each successive generation will rapidly become
displaced by the next. We will all need to learn humility. In a world of IQ uplift, everyone will
eventually be considered as mentally disabled relative to the leading edge. We all need to
think like egalitarians. There will be overwhelming wealth created, though it will be impossible
to maintain elite dynastic control for even a short period of time. The actual consequences for
trying to achieve this would be something that I would most definitely not enjoy having to
live with.


The big problem here is that the idea of IQ uplift has never been widely introduced into the public imagination.
This is true even now.

Science fiction never allowed us to imagine the world that we now confront.
We were not given decades to dream about how our life would be.

Yet, here we are.
IQ uplift might already have begun and people seem very oblivious to what is happening.

One day we might wake up and the kids had built a multi-dimensional time portal.
What then?

There is broad mainstream recognition of the ideas from Brave New World.
Even today it is cited as the world of the future created by genetic engineering.
However, it is wrong in one very important respect: The alphas were not that smart.
The alphas behaved in a way consistent with 200 IQ.

Current science tells us that this is completely incorrect.
It is laughably incorrect.
People who suggest this now would be open to unconcealed ridicule.

Alphas will not have 200 IQ; they will have 1000+ IQ.
We have no idea what 1000+ IQ behavior would be like.
However, we can be completely confident that it would be nothing like that depicted in Brave New World.

Perhaps the best description would be that those with maximal enhancement would not be human as we understand
it, but more like a divine presence. There is no obvious reason why such mind forces would have any particular interest in humans.

[aboe4]

this is interesting J11, although I agree it is difficult to follow the nuances of the study from 2014 that you've shared. Can you explain the left and right y-axis units as well as the x-axis in that chart?