I just found out about this gene via Prometheus report and wondered if others knew of it or had it also. There is a protective allele decreasing risk of AD apparently and I was wondering how this might affect those of us with APOE4. It relates to the clearance of amyloid plaques in the brain. It seems less expression of CD33 the better, and this rarer allele does this. It seems to be a target for potential therapy agents for AD.
"Based on the contributing effects of CD33 in AD pathogenesis, targeting CD33 may provide new opportunities for AD therapeutic strategies." CD33 in Alzheimer's disease. https://www.ncbi.nlm.nih.gov/pubmed/23982747
"The minor allele of the CD33 SNP rs3865444, which confers protection against AD, was associated with reductions in both CD33 expression and insoluble amyloid beta 42 (Aβ42) levels in AD brain." Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. https://www.ncbi.nlm.nih.gov/pubmed/23623698
Here is the most recent article I found, from this Sep. Unfortunately the full article is not available.
"An SNP that modulates CD33 splicing to favor CD33m is associated with enhanced microglial activity. Individuals expressing more protective isoform accumulate less brain β-amyloid and have a lower LOAD risk." "The CD33 allele that protects post-reproductive individuals from LOAD may have evolved by adaptive loss-of-function, an example of the less-is-more hypothesis."
CD33 Protective role in AD
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Orangeblossom
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Orangeblossom
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Re: CD33 Protective role in AD
This is interesting. Seems this CD33 polymorphism may have evolved over time and protects from AD...
Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline
http://www.pnas.org/content/113/1/74.long
"the LOAD-protective CD33 allele represents a derived state in humans, having evolved after our common ancestor with other hominids, and possibly after our common ancestor with Neanderthal and Denisovans 550,000–765,000 y ago"
"CD33 and APOE Underwent Comparable Evolutionary Changes. We noted that the evolutionary history of CD33 is similar to that of APOE, in that both genes have derived alleles that protect from a novel liability that is uniquely human"
"CD33 and APOE Underwent Comparable Evolutionary Changes. We noted that the evolutionary history of CD33 is similar to that of APOE, in that both genes have derived alleles that protect from a novel liability that is uniquely human"
Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline
http://www.pnas.org/content/113/1/74.long
"the LOAD-protective CD33 allele represents a derived state in humans, having evolved after our common ancestor with other hominids, and possibly after our common ancestor with Neanderthal and Denisovans 550,000–765,000 y ago"
"CD33 and APOE Underwent Comparable Evolutionary Changes. We noted that the evolutionary history of CD33 is similar to that of APOE, in that both genes have derived alleles that protect from a novel liability that is uniquely human"
"CD33 and APOE Underwent Comparable Evolutionary Changes. We noted that the evolutionary history of CD33 is similar to that of APOE, in that both genes have derived alleles that protect from a novel liability that is uniquely human"
