https://alzheimer-prevention.com/
Re: https://alzheimer-prevention.com/
Hi, at the risk of further hijacking this thread, I just wanted to acknowledge the points raised by Stavia and SusanJ regarding the possible downsides to mTOR hacks...sarcopaenia, and who knows what else. I think you are very sensible Susan, in taking a break from supplements to see if you feel better, or worse. Maybe we should all do that from time to time. I have considered giving away the Bs and TMG at some point if the homocysteine fails to drop... the courier just dropped off the iHerb box though, with the next addition to my regime... Sunflower lecithin and Collagen peptides. We shall see. Very interested to hear how your next tests go Susan.
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Re: https://alzheimer-prevention.com/
Hi Suzy,
You are correct. Most studies on RAPA are experimenting with it as anti-cancer drug. As anti-cancer drug usually use daily at high dose.
Everybody understands you take cancer drugs to hurt cancer cells, not help patient's cells.
Use of RAPA as anti-aging drug very different.
You are correct. Most studies on RAPA are experimenting with it as anti-cancer drug. As anti-cancer drug usually use daily at high dose.
Everybody understands you take cancer drugs to hurt cancer cells, not help patient's cells.
Use of RAPA as anti-aging drug very different.
Re: https://alzheimer-prevention.com/
Dr. Green,
Could you clarify? On your site, you reference a study that says a statin that crosses the BBB reduce HR ?? for AD.
I think it was simastatin. BUTon Wiki protocol on this web they say stay away from statins that cross BBB, inducing brain fog???
Thanks, jeff
Could you clarify? On your site, you reference a study that says a statin that crosses the BBB reduce HR ?? for AD.
I think it was simastatin. BUTon Wiki protocol on this web they say stay away from statins that cross BBB, inducing brain fog???
Thanks, jeff
Re: RE: Re: https://alzheimer-prevention.com/
Jeff, the science around statins is not black and white. Some studies show a possible benefit, but others don't, and some researchers have found mechanisms whereby statins may be harmful.jeff wrote:Dr. Green,
Could you clarify? On your site, you reference a study that says a statin that crosses the BBB reduce HR ?? for AD.
I think it was simastatin. BUTon Wiki protocol on this web they say stay away from statins that cross BBB, inducing brain fog???
Thanks, jeff
My personal interpretation of the evidence is a middle ground and would be broadly accepted by most in mainstream medicine. This is not medical advice to you but an explanation of my position. Which may differ from others.
I would not personally take a statin or recommend one to my patients purely for AD prevention because I believe that the possible harms (muscle issues, rare liver issues, sometimes brain fog) in this situation outweigh the benefits. This is what the wiki is alluding to.
However I am very comfortable prescribing statins to my patients with established heart disease such as angina or previous heart attacks, and with a previous stroke caused by a clot (not a bleed). In these situations I follow the mainstream consensus and believe that the benefits outweigh the harms.
Statins are complicated. Its not always black and white.
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Re: https://alzheimer-prevention.com/
Stavia's right, as usual. I tend to be a bit more pro-statin but that's because of my particular situation (gotta take CVD seriously).
There's an ongoing statin thread here which recently discused two studies showing statins reduce risks of AD, with greater benefit for 4/4s. Both water soluble and fat soluble statins seemed to have some benefit. One is from the Rotterdam study. Check that out if you are interested. Some of the most encouraging data - in humans - I have seen in a while.
That said, I suspect the balance of pros and cons for statins change over time, and for those with side effects.
We'd all be well-served if the AD aware doctors and the cardiologists would battle it out and develop a set of common recommendations IMO. Their cultures and patient needs are different.
There's an ongoing statin thread here which recently discused two studies showing statins reduce risks of AD, with greater benefit for 4/4s. Both water soluble and fat soluble statins seemed to have some benefit. One is from the Rotterdam study. Check that out if you are interested. Some of the most encouraging data - in humans - I have seen in a while.
That said, I suspect the balance of pros and cons for statins change over time, and for those with side effects.
We'd all be well-served if the AD aware doctors and the cardiologists would battle it out and develop a set of common recommendations IMO. Their cultures and patient needs are different.