https://alzheimer-prevention.com/

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
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Stavia
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Re: https://alzheimer-prevention.com/

Post by Stavia »

Hi Alan
Thank you for your point of view and detailed information about rapamycin. I await future information and possible trials with great interest.

Bredesen's protocol is not 100% MTOR orientated but far more multifaceted than that one single pathway.

You might want to read his book, listen to a YouTube lecture or view some of my notes on his lectures during our meetups over the years.
Other critical factors are, in no particular order, areas such as trophic support (eg Tsh, estradiol), mitochondrial function, BDNF, cognitive reserve, glycaemic control, inflammation etc etc.



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cal.matheny
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Re: https://alzheimer-prevention.com/

Post by cal.matheny »

Does the Dr. Bredesen's diet include no water?
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Re: https://alzheimer-prevention.com/

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cal.matheny wrote:Does the Dr. Bredesen's diet include no water?
Welcome cal.matheny.

There is no limitation to drinking water in the Bredesen protocol as I understand it. Inhaling water is not recommended. What have you seen to trigger the question? When you are ready, please introduce yourself in the "Our Stories" forum. We'd like to know more about you.
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Re: https://alzheimer-prevention.com/

Post by Lucy5 »

alangreenmd wrote:
I have been on intermittent weekly rapamycin for 2 years. No side-effects. I would estimate intermittent rapamycin (6mg once a week) is probably like 30-40% caloric restriction as regards lowering mTOR.
I've found the discussions here re: rapamycin thought provoking. As a 64 y/o 4/4, reducing mTOR is one of the areas I've been focused on, but CR is not an option for me (due to a lifelong low BMI - a family thing it appears), and so I have to be careful with fasting as well.

For a few years now I've been following a couple of research oriented anti-aging websites (Josh Mitteldorf's Aging Matters blog as well as AntiAging Firewalls by James Watson and Vince Giuliano) where rapamycin has been discussed in some detail. I believe one of the possible side effects of this drug has been increased blood glucose and I've read that some folks experimenting with it also take metformin to counteract that effect. I'm wondering if intermittent use of rapamycin (Dr. Green?) has been found to impact blood glucose/insulin resistance?

Definitely not saying I would go down this road, but like to know as much as I can about possible options at some point...
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Re: https://alzheimer-prevention.com/

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Once again, I have to conclude that if I was a mouse then I'd be very encouraged by the progress of Alzheimer's research.

As a human, I'm inclined to wait for the FDA to decide about phase III clinical trials...
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Re: https://alzheimer-prevention.com/

Post by alangreenmd »

Hi Brian,

Another paper to review is "a Perfect sTORm: Role of mTOR in cerebrovascular dysfunction in AD, Veronica Galvan (one of AD superstars since 2010).

You cite a few ways to achieve reduction mTOR. Ketogenic diet reduces mTOR, again don't know how much. Between CR, special diets (low red meat, low milk products, low sugar etc), ketogenic diet, physical activity can lower mTOR. Best way lower mTOR, avoid obesity and overweight.
However, since more and more people not APOE4 carriers now going on weekly rapamycin to protect against ordinary age-related stuff, seems like a good idea if APOE4 carriers.

Trying to put together a study to actually prove it with neuroimaging.
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Re: RE: Re: https://alzheimer-prevention.com/

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Nords wrote:Once again, I have to conclude that if I was a mouse then I'd be very encouraged by the progress of Alzheimer's research.

As a human, I'm inclined to wait for the FDA to decide about phase III clinical trials...
Yup.
I believe, from my interpretation of the body of evidence, that AD is far more than mTOR related alone. I'll keep mine down with IF, excercise etc etc in the meantime, and await future information with interest.
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Re: https://alzheimer-prevention.com/

Post by Brian4 »

As a human, I'm inclined to wait for the FDA to decide about phase III clinical trials...
Many of the components of the regimens followed by most here haven't undergone Phase III trials for the indication of Alzheimers. People do the cost-benefit analysis for a particular treatment, and often decide to try the pill/supplement/herb/etc., knowing there will be risks.

The only reason I'm not on weekly rapamycin is because I keep mTOR signalling very low with my diet.

That said, more research is always a good thing. Even a small pilot study ("phase 0") would yield useful data.

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Re: https://alzheimer-prevention.com/

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Rapamycin is an immunosupressant drug and as such is FDA regulated. Not in the same ballpark as curcumin for instance.

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Re: https://alzheimer-prevention.com/

Post by Julie G »

Good warning about off-label drug use, Stavia. It’s a subject near and dear to my heart. At age 12, my son inexplicably became critically ill and was unable to eat without vomiting. The only FDA approved drug for his condition, reglan, caused him to have severe neurological side effects. We were stunned to learn that there was nothing else available at the time. His BMI dropped to 17. He was so weak that all he could do was lie in bed. Local docs couldn't help and we ultimately landed at Johns Hopkins where my son’s GI put him on a very tiny dose of eyrthromycin, completely off-label. In minute amounts, it also works as a GI prokinetic. We were told that the reason there were no other FDA approved drugs for this condition was that it wasn’t profitable for drug manufacturers to market a generic with an expired patent for a different use. An off-label use of a drug, along with many other strategies, ultimately restored my son to having a normal life. Here’s a good article going over the pros and cons of using drugs off-label.

I just stumbled upon this Q&A last night providing an overview of the possible benefits of rapamycin for E4 carriers. (Be sure to read the comments.) It’s an intriguing application. I do have a concern, however, from reading this paper. Rapamycin, apparently, impedes cholesterol from effectively getting into cells and causes an escalation. Isn’t this already a problem for E4 carriers? I also question the use of statins to address this. Don’t our cells NEED cholesterol? I want to learn more...
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