jasonkivo wrote:[mention]TreeHugger [/mention]
Matt - how’s the Prodrome trial going? I finally stumbled on this idea and saw your posts. Are you still taking it? Any new thoughts? I see it’s $299 for a bottle is that good for a month or do you take more than recommended. Thank you!
TreeHugger wrote:Since desaturase is the final conversion step of Prodrome-Neuro to plasmalogen and I am homozygous for many, many FADS2 and FADS1 SNPs, will these SNPs result in less plasmalogen per fixed dose of Prodrome-Neuro?
Jason, welcome aboard! I am responding fantastically to Prodrome-Neuro. I am taking 1.8 ml each day, which is double the recommended starting dose, but I believe that I have special needs for DHA-rich phospholipids/plasmalogens thanks to my genes.jasonkivo wrote:Matt - how’s the Prodrome trial going? I finally stumbled on this idea and saw your posts. Are you still taking it? Any new thoughts? I see it’s $299 for a bottle is that good for a month or do you take more than recommended.
Circular, desaturase is at a place in the pathway of plasmalogen production that it should be involved in both endogenous plasmalogen production and Prodrome-Neuro conversion. My guess is that the DHA molecule on each Plasmalogen-Neuro which is split from PN during digestion/absorption is also absorbed as a free fatty acid and reattached later and so this bypasses my low performing FADS.circular wrote:Hi TreeHugger, Have you learned anymore about this? I also have a healthy dose of homozygous FADS mutations. And are these involved in plasmalogen synthesis in the body naturally or just with the way the supplement works ... if you know?
Good advice. I've discontinued or reduced several other supplements in response to my reaction to this new combo. The most surprising change: I started having major problems with hormone replacement therapy, so I have discontinued HRT after 12 years. My adrenal glands are once again producing normal levels of all steroids. I don't have blood level confirmation yet as I'm too chicken to go to the lab due to SARS-Cov-2, but I still consider this an objective change as I literally couldn't function while on HRT. Subjectively I've started having "magic" days where my cognition is greatly increased.circular wrote:One thing you could consider trying, now that you feel sure you need all five components, would be halving them one by one just to check whether you need doses as high as you’re using.
I had all of my amalgams removed in early 2017 after my health declined even though I'd started following ReCODE. I liquidated a life insurance policy and flew to Costa Rica to have the work done by an IAOMT trained dentist for roughly 1/3 of the US cost ($4,000 instead of $11,000 with airfare, lodging, and meals). I've heard that some folks have gotten their insurance to pay for the replacement of "old" fillings and crowns. I've been chelating using Andy Cutler's chelation protocol since then with slow but continuous improvement. For example, chelation restored by ability to eat cruciferous vegetables after 1.5 years (just in time to discover Plant Paradox). I've noticed that for me the redistribution symptoms that accompany the start and end of a round of chelation are greatly suppressed with Prodrome-Neuro. I suspect this is because plasmalogen is preferentially attacked by mercury (https://www.ncbi.nlm.nih.gov/pubmed/29269315) and increasing serum plasmalogen reduces cellular stress caused by the membrane damage resulting from mercury freed by chelation.circular wrote:Have you had your mercury fillings removed? I have a complicated mouth too and the cost of doing the supposedly desired protocol would be in the thousands and pose a whole new set of risks. So, I’m leaving well enough alone and hoping to adequately support my detox and overall health to counteract it. I have one exposed mercury filling I may have removed; the others are under crowns if they’re there, thanks to a lifetime of ‘soft teeth’.
babl wrote:I got my first shipment of ProdromeNeuro Plasmalogen oil today! Woot! The suggested dosage says 1 ml per day, mixed into a beverage. I'm curious how others are taking this? Treehugger? Anyone else? Does it have a taste or aftertaste? Is it better mixed with certain beverages? Excited to get started on this, especially after reading Treehugger's reports (thanks)!!
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