Plasmalogens- exciting new evidence

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NF52
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Re: Plasmalogens- exciting new evidence

Postby NF52 » Sun Mar 04, 2018 7:00 am

Ah Searcher,
I well remember reading long ago about the Fore people (more women than men, due to their roles) who suffered from fatal neurodegenerative kuru due to their beliefs about helping their loved ones to the afterlife. The Fore's kuru was recognized as similar to Creutzfeldt–Jakob disease, hence the discovery of prions. Younger readers will remember the panic around "mad cow disease"

My shaky memory is that scientists who learned about prions paved the way to discover mis-folded proteins in Alzheimer's. Sixty years later I'm taking a BACE-1 inhibitor (or placebo) which may keep my brain's protein's nicely formed for a few more years. In that spirit, I'm not opting for any grass-fed, organic lamb brains!

Your post prompted me to find this book, which will remind me that the subjects of research and the researchers themselves may both benefit and suffer in the quest for knowledge. The Collectors of Lost Souls: Turning Kuru Scientists into Whitemen, by Warwick Anderson.

To quote (and slightly amend) Theodore Parker, a Transcendentalist, minister, abolitionist and 1853 author of MLK's famous quote:

I do not pretend to understand the moral [and scientific] universe, the arc is a long one, my eye reaches but little ways. I cannot calculate the curve and complete the figure by the experience of sight; I can divine it by conscience. But from what I see I am sure it bends towards justice [and interconnectedness among all peoples].
4/4 and still an optimist!

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Stavia
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Re: Plasmalogens- exciting new evidence

Postby Stavia » Sun Mar 04, 2018 9:47 am

Yeah. I didn't think of this. Good catch.
I see plasmalogens are abundant in heart tissue too. Is that accessible in your country?
Otherwise you're all going to need to move here to eat green lipped mussels and pasture fed sheep hearts. I can pitch tents in my garden.

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Re: Plasmalogens- exciting new evidence

Postby circular » Sun Mar 04, 2018 10:28 am

For kicks, not medical advice, you might consult your Promethease results for PRNP rs1799990. Upon very cursory skim, heterozygous seems to be most protective (A,G) against CJD. I get homozygous G,G which unfortunately, while conferring some protection against CFD, also appears to impair plasticity in the memory-forming network ... but simultaneously lowers risk for AD? :? I'll let you all pick it apart if you want since I have to refocus elsewhere in life, but take note -- no surprise --:
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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Re: Plasmalogens- exciting new evidence

Postby chrissyr » Mon Mar 05, 2018 5:11 pm

Yes, pitching tents in Stavia's garden!!
But I still won't eat the sheep hearts, mussels sound good :)

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Re: Plasmalogens- exciting new evidence

Postby Tincup » Mon Mar 05, 2018 8:48 pm

Searcher wrote:IDon't ask which brains.

Yes, I recall cannibalism was an issue. Likewise in Mad Cow, it was when they put cow brains back into cow feed that was the issue.

I also recall that prion illnesses occur spontaneously in 1 out of a million, or something like that, cases. It is when one consumes the brains in a feeding situation that numbers of cases get much larger.

In our area CWD (chronic wasting disease) is an issue in deer and elk populations. As I understand, they still aren't sure if CWD can be transferred to humans.
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Re: Plasmalogens- exciting new evidence

Postby stana » Sat Apr 07, 2018 1:56 am

Hi,

Reading topic with interesse, and found this product (NeuroREGAIN - Scallop-derived PLASMALOGEN ) on Amazon.com. Has anyone tried it yet?

Rgds,
Stana

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slacker
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Re: Plasmalogens- exciting new evidence

Postby slacker » Sat Apr 07, 2018 5:10 am

Welcome Stana;

I searched the site (magnifying glass icon at right top of page) with no hits other than yours. Doesn't mean that someone else won't pipe in with experience!
When you are ready, please tell us more about yourself in the "Our Stories" Forum.
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Re: Plasmalogens- exciting new evidence

Postby Karengo » Sat Apr 07, 2018 3:32 pm

Greetings Stana: Welcome to our community! I see you first joined us a while ago. I'm pleased to see you've taken the leap to make a comment and post here. I'm curious to see if other members are familiar with the product you mention.

In case you haven't discovered the Primer yet you'll find it's a great resource created by physician member, Stavia. And as slacker mentioned above, whenever you feel like sharing more about your story and your health journey - or reading about others - please do! Here's the link for you OurStories

Again, we're glad you're here! Please feel free to ask questions and remember your comments are always welcome!

Best,
~Karengo
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"For whatever we lose like a you or a me, it's always ourselves we find in the sea"

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SusanJ
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Re: Plasmalogens- exciting new evidence

Postby SusanJ » Wed May 30, 2018 5:59 am

So, recent research on why plasmalogens decrease in AD patients.

In the new study, Gross' team performed painstaking experiments to find the elusive mechanism by which plasmalogens are enzymatically degraded. Cytochrome c is typically found in mitochondria where it facilitates electron transport, but it is released into the cell under stressful conditions. Gross' team showed that cytochrome c released from the mitochondria can catalyze the breakdown of plasmalogens in the cell. Further, the products of this reaction are two different lipid signaling molecules which were not previously known to originate from plasmalogen breakdown.

"That was one thing that surprised us," Gross said of the signaling products. "The second thing that surprised us was the ease (with which the bond is broken)...The implication is that there is probably a lot of plasmalogen (breakdown) that's going on in conditions of oxidative stress." The results tie in with another observation about the brain cells of Alzheimer's disease patients, which is that they often have dysfunctional mitochondria and a resultant release of cytochrome c. Gross is now interested in delving deeper into how and why plasmalogen loss occurs in Alzheimer's patients, particularly those who develop the disease in old age, not due to familial mutations. Gross speculates that as people age, the accumulation of reactive oxygen species leads to cytochrome c release, activation of its peroxidase activity and plasmalogen breakdown in many membranes.

https://www.sciencedaily.com/releases/2 ... 185346.htm

Full paper at http://www.jbc.org/content/early/2018/0 ... 9.full.pdf

Oxidative stress, yep, we know it can be bad and this gives us another clue why.

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Re: Plasmalogens- exciting new evidence

Postby MoJoe » Fri Jul 27, 2018 3:00 pm

Neuroregain contains around 1 mg of E-Plas per capsule, many diets contain higher levels. I suspect any effect on AD would be dose dependant and 1 mg of plasmalogen may be a bit light. Also C-Plas appears to be pro- inflammatory so the chicken version of plasmalogens may not be as effective.


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