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what is the prevelance of atrophic Alzheimers

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Stefan
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what is the prevelance of atrophic Alzheimers

Postby Stefan » Tue Feb 20, 2018 7:45 am

Dale Bredesen talks of 3 subtypes of Alzheimers. Does somebody know what is the prevalence of the atrophic Alzheimer type in relation to the sum of all known Alzheimer types? I could not find a reference in his papers. He talks only of subtype 3, the toxic A., being about 10 % of the total....

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Re: what is the prevelance of atrophic Alzheimers

Postby Sara » Tue Feb 20, 2018 2:17 pm

Greetings Stefan. This is a great question and I'm sure someone will have an answer for you. I'll check back in later and if we don't have an answer for you I will dig in and see what I can find out.
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Re: what is the prevelance of atrophic Alzheimers

Postby Jlhughette » Tue Feb 20, 2018 4:11 pm

Hi Stefan,

I don’t know the prevalence of it either except to offer that my Bredesen trained doctor said that she has had good outcomes treating the atropic type.

I’m curious to know as well.
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Re: what is the prevelance of atrophic Alzheimers

Postby NF52 » Tue Feb 20, 2018 4:27 pm

Stefan wrote:Dale Bredesen talks of 3 subtypes of Alzheimers. Does somebody know what is the prevalence of the atrophic Alzheimer type in relation to the sum of all known Alzheimer types?


Hi Stefan,
I think the quick answer to your question is this: Dr. Bredesen's description of types of Alzheimer's is based on his research and clinical practice. It is not currently used widely as a diagnostic or categorization methodology--the whole field of diagnosis is still evolving! Research studies of the incidence of Alzheimer's now mostly focus on using consistent criteria across studies, which mostly have to do with degree of significant change on various measures, or evidence of neuro-degeneration paired with clinical signs of loss of function.

So if someone is evaluated for Alzheimer's, he or she may have a variety of tests (blood tests, imaging tests such as an MRI, more rarely a PET scan, and neuropsychological tests of memory, visual processing, daily living skills, new learning etc.) Based on those tests, the person may meet a cut-off of functioning below typical for people that age and be given a diagnosis of "mild cognitive impairment", "vascular dementia", "Lewy Body Dementia" Posterior Cortical atrophy, or Alzheimer's.
In general, it's likely that in the recent past, many people died "with" dementia, but without the diagnosis of it, and others probably were "diagnosed" with Alzheimer's, but may have had vascular dementia, or other causal illnesses.

I wouldn't rely too heavily on percentages for types; it's more important to look at what your own risk factors might be and work on those.

Hope this helps!
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Re: what is the prevelance of atrophic Alzheimers

Postby Stefan » Wed Feb 21, 2018 12:24 am

Hi NF
I want this info just for the sake of knowledge, as i am writing my homepage. I think it is an important figure to be known to the public. And Dale Bredesen mentions in a 2016 paper that the toxic A is about 10 % of the total. Myself being a 4/3 i have run quite a few blood tests, but not having symptoms i try to keep my blood values optimal. And knowing if the percentage of the cold A is 20 or 50 % , with the info on the blood parameters for this type of A given by Bredesen i could optimise my prevention strategy. Anyway i will be having a seminar with Dale Bredesen this spring and will ask him personally this question...

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Re: what is the prevelance of atrophic Alzheimers

Postby aphorist » Fri Feb 23, 2018 12:24 pm

How does the treatment for Atrophic differ from the other subtypes?

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Re: what is the prevelance of atrophic Alzheimers

Postby floramaria » Fri Feb 23, 2018 3:49 pm

aphorist wrote:How does the treatment for Atrophic differ from the other subtypes?


Treatment for atrophic subtype prioritizes optimizing hormone levels.
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Re: what is the prevelance of atrophic Alzheimers

Postby floramaria » Fri Feb 23, 2018 4:09 pm

Stefan wrote:Hi NF
I want this info just for the sake of knowledge, as i am writing my homepage. I think it is an important figure to be known to the public. And Dale Bredesen mentions in a 2016 paper that the toxic A is about 10 % of the total. Myself being a 4/3 i have run quite a few blood tests, but not having symptoms i try to keep my blood values optimal. And knowing if the percentage of the cold A is 20 or 50 % , with the info on the blood parameters for this type of A given by Bredesen i could optimise my prevention strategy. Anyway i will be having a seminar with Dale Bredesen this spring and will ask him personally this question...


This is just my opinion based on my understanding, and certainly not definitive. My understanding is that the subtype categorization helps to understand what contributing factors are most likely the most important ones having the greatest impact. That can guide interventions. For example, if inflammatory markers are the ones most out of the ideal range, then that might be first area of focus. If markers of insulin resistance show up, then that would be the first priority. The sub-types often overlap. In some recent interviews, I have heard Dr Bredesen state that he has been taken by surprise with the number of type 3 markers he is seeing and that some level of toxicity is much more common than he expected. a friend of mine’s father who was experiencing cognitive decline tested with the highest level of mercury that his doctor had ever seen. Reducing his mercury brought some improvement right away. But that doesn´t mean that if his HbA1c is high, he wouldn´t need to worry about his blood sugar ¨because he is a Type 3¨.
For me, personally, I have not sustained many knocks to the head, my inflammatory markers were good and blood sugar markers were good and hormone levels were almost nothing, so I have been thinking of myself as mainly Type 2 and taking steps to get all the hormones in line. Meanwhile I am checking my heavy metals (results next week) and have looked at the blood markers for CIRS (results good). If Mercury or lead comes back very high, it may be that I would be classified as Type3 and that toxicity is the biggest factor to be looking at. But that would not mean that optimizing hormones was not important. It is easier to say what a subtype is when all of the testing has been done at once, so the comparative “out-of -whackness” of each area can be evaluated.
Again, this is just my interpretation.
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Re: what is the prevelance of atrophic Alzheimers

Postby Stefan » Sat Jan 26, 2019 10:38 am

Coming back to the AD subtypes. I asked Dr Bredesen at the London seminar on the prevelance of the different main subtypes. He said they are most often mixed, the prevelance of each type being: inflammatory: about 10%, trophic about 30-40%, toxic being the most prevalent being around 50-60%. I was surprised that the toxic has the highest prevalence!!
I cite that a US nutrigenomics company:
At Lifecode Gx, the APOE Plus DNA Test can help identify and analyse these three subtypes based on genetic results.named at https://medium.com/@LifecodeGx/the-thre ... a688423e89 that
i hope this helps
according to my blood valued and my nutrigenomics analysis, being a 4/3, i guess that I have to prevent a dement mixture of the 1.5 and the trophic type.....

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Re: what is the prevelance of atrophic Alzheimers

Postby TheBrain » Tue Jan 29, 2019 6:11 am

Stefan, thanks for sharing this information with us. I’m not surprised that the toxic subtype has the highest prevalence, given all I’ve learned about mold toxicity, which is one of the issues I’m dealing with. Unfortunatley, mold toxicity is still largely unrecognized. Of course, there are other causes of toxicity, but mold is a big one.
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