Hi Orangeblossom,Orangeblossom wrote:A first-of-its-kind study has found that 'skinny fat' -- the combination of low muscle mass and strength in the context of high fat mass -- may be an important predictor of cognitive performance in older adults.
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the ElderlyThis is the first study, to our knowledge, to report that sarcopenic obesity precedes and predicts the onset of IADL disability in a sample of community-dwelling elderly. Our data suggest that nondisabled elderly with sarcopenic obesity are 2.5 times more likely to report subsequent IADL disability over a 7-year follow-up than individuals without sarcopenic obesity, regardless of age, sex, level of habitual physical activity, and morbidity. “Pure” sarcopenia— or sarcopenic nonobesity—and obesity without sarcopenia were not significantly associated with the onset of IADL disability in this study, which contrasts somewhat with reports from previous cross-sectional studies for significant positive associations.
There are several limitations of this study that should be recognized. First, the study cohort was small, and sarcopenic obesity was rare, limiting the statistical power to detect associations. The small sample size also limited our ability to analyze potentially confounding associations with incident morbidity. Although our data suggest that the association of sarcopenic obesity with incident IADL disability is independent of major prevalent comorbidities, it remains possible that this association is confounded by underlying, “preclinical” morbidity... It has long been recognized that proinflammatory cytokines, tumor necrosis factor and IL-6 in particular, are associated with muscle wasting in cachexia through stimulation of protein degradation through the ubiquitin–proteosome pathway. Roubenoff has proposed that chronic low levels of these cytokines caused by age-associated increases in adiposity may result in an enhancement of the more subtle, gradual loss of muscle that characterizes sarcopenia (37). Thus, sarcopenia may be accelerated in individuals with long-standing obesity and its associated chronic inflammatory status, resulting in sarcopenic obesity in old age.
PeteWilliams wrote:This is something we look to measure in all our patients.
We do this in two ways HT to waist ratio...
And for those who can afford it, we use Dexa Scanning to get more gold standard measures. This does prove an enlightening experience for most! In fact, all patients perceive to be at least 15% lower than they are. It's a great tool and motivator when they realise how much body fat they have.
PeteWilliams wrote:I look for functional capacity, in other words, some can be sarcopenic but have high functionality and strength. A term called dynapenia. The more functional they are the more likely they move and that has huge positive implications for Cognition.
PeteWilliams wrote:Karengo, Dexa should be all over the place and cheap to do.
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