New paper from Dr. Gundry on stopping progression of CAD

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Julie G
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New paper from Dr. Gundry on stopping progression of CAD

Postby Julie G » Thu Aug 09, 2018 11:45 am

I can only get the abstract (for now.) It's published in the American Heart Association journal. It's a real paper, not a poster, and has lots more detail than previous publications. I wish we knew the breakdown of APOE status...

A High Dose Olive Oil, Polyphenol, and Lectin Limited Diet Reverses and/or Stabilizes Advanced Coronary Artery Disease
https://www.ahajournals.org/doi/abs/10. ... uppl_1.404
Abstract
Introduction: Coronary Artery Disease (CAD) is thought to be progressive; standard treatment protocols call for instituting a low fat/low cholesterol diet program, exercise, and lipid lowering agents. This results in an approximate 30-40% new event rate in 5 yrs. We evaluated our treatment strategy to reverse CAD with The Corus Score (CS) (Cardiodx, Redwood City, Ca), proven to quantify coronary artery obstructive plaque by the expression of 23 genes.

Methods: Based upon using a Lectin-limited diet to prevent/reverse Metabolic Syndrome and CAD, we have enrolled and followed 800 pts (aged 42-89 yrs) with known CAD, defined as previous MI, stent, CABG, or positive stress test/angiogram, positive CS greater than 30, into a physician coached program, which reduces grains, legumes, nightshades, seeded vegetables, Casein A1 milk, (the all lectin containing food groups),and fruits; emphases consumption a liter of olive oil/wk, large amts of green vegetables, and 4 oz amts of proteins, avoiding commercial poultry (Matrix Protocol). All Apo E 4 genotypes avoided animal fats and cheeses. Pts were instructed to take 4,000 mg of high DHA fish oil, 200mg of Grape Seed Extract, and 25 mg of Pycnogenol per day, and consume polyphenol rich coffee and/or teas and 1 oz dark chocolate/day. Diets/supplements were individualized based on results of Advanced Cardiovascular Risk Markers (ACRM), which were sent to two core labs. Yearly assessment of CAD severity was measured by Corus Score (possible range 1-40). Any score above 30 was assessed by Nuclear Stress testing.

Results: Pts have been followed for 1.5 to 6 years (mean 4.5 yrs). Only 6/800 pts (0.5%) have received a new stent, all 6 had rising Corus scores: two also had a rising Lp-PLA2, 2 had rising Cardiac Troponin I levels; one pt required CABG: . There have been no MI’s, unstable angina. Corus scores at baseline decreased from 34+/-4 (range 6-36) to 24+/-3, P<0.01. Only 64/800 pts (8%) had a rise in Corus scores/ 736/800 pts’ CS declined or remained stable (92%). Only 6/64 Corus scores had positive Stress tests.

Conclusions: Simple Nutrigenomic-based dietary interventions, based upon ACRM's and Corus Scores, represents a quantum leap forward in preventing/modifying Cardiovascular events in known CAD patients.

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Fiver » Thu Aug 09, 2018 12:58 pm

Hi. Looks encouraging. And *polyphenols*!

Looks like the link goes to a conference poster abstract, published in the journal's supplement section. There might be a companion paper out there somewhere. Sometimes they make it so confusing. IF there is a companion paper it could be embargoed for release at a future time.
Concerned, but hopeful. Introverted, but will talk about science.

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Julie G » Thu Aug 09, 2018 2:04 pm

Well... duh! Thanks for pointing that out ;) I still appreciate the amount of detail, especially about the cases that didn't stop progression. Rings true.

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Tincup » Thu Aug 09, 2018 5:25 pm

Here is this abstract: 412 — 2018 ATVB
Presentation slides

Dietary Lectins Cause Coronary Artery Disease via an Autoimmune Endothelial Attack Mediated by Interleukin 16

Immune Mechanisms of Atherosclerosis

Presented on Friday, May 11, 2018 5:30 PM
Author(s): Steven R Gundry, The Intl Heart and Lung Inst, Palm Springs, CA

Interleukin 16 (IL-16) is a chemoattractant released by endothelial and other cells to attract activated T cells. It has previously been shown to have expression in many autoimmune diseases (AI). Based on our previous reports using elevated adiponectin levels of 16 ug/mL to predict lectin sensitivity, and showing an association between lectins and AI causation, we have treated a large pt population with known autoimmune disease (as confirmed by markers). We recently began using the PULS Cardiac Test (GD Biosciences Lab, Irvine, CA) a validated blood test for predicting 5 year risk of acute coronary syndrome (ACS) to examine which measured biomarkers predominate in these patients.
325 consecutive pts aged 25-89 had PULS tested as part of a comprehensive blood panel, which also screens for 14 autoimmune disease markers. The PULS tests ranks 9 biomarkers, including IL-16, MCP-3, Eotaxin, CTACK, sFas, Fas Ligand, HGF for ACS risk, ranking each biomarker from lowest to highest level contributing to risk.

241 pts (74%) were positive for elevated adiponectin, hx of AI, and/or markers for AI. Of these pts, 223 (93%) were positive for IL-16 as the highest PULS risk factor. In contrast, of the other 84 pts without AI or adiponectin elevation, only 5 (6%) had IL-16 recorded as a risk.
We conclude that based on IL-16 testing via PULS, that this provides further evidence to support an autoimmune cause of coronary artery disease at the endothelial level via T cell activation and attraction in patients with gluten and lectin sensitivity or known autoimmune disease. It also explains the known high association of autoimmune disease and ACS
Disclosure: S.R. Gundry: None.
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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Tincup » Thu Aug 09, 2018 5:27 pm

And this one
Presentation slides
P238 — 2018 EPI
Remission/Cure of Autoimmune Diseases by a Lectin Limite Diet Supplemented With Probiotics, Prebiotics, and Polyphenols

P02 | Nutrition

Presented on Wednesday, March 21, 2018 5:00 PM
Author(s): Steven R Gundry, The Intl Heart and Lung Inst, Palm Springs, CA

All autoimmune diseases are highly associated with increased rates of coronary artery and vascular disease secondary to immune cell attack on epithelial cells. The causes of autoimmune disease (AID) seem to be multifactorial. However, the idea that derangement of the microbiome, breaches of the intestinal barrier (leaky gut) and introduction into the human diet of plant defense molecules such as lectins, which are capable of molecular mimicry, prompted our group to investigate the application of a lectin limited diet, coupled with probiotics and prebiotics (The Pant Paradox Protocol) to impact biomarker proven autoimmune disease activity in humans and their impact on endothelial biomarkers of inflammation.

One hundred and two consecutive patients with immunoassay markers of autoimmune disease activity, i.e., RF, anti-CCP, ANA, Histone, etc, and signs and symptoms of RA, Lupus, Sjogrens, Crohns, Colitis, Scleroderma, Mixed Connective Tissue Disease, and biomarkers of endothelial inflammation, were enrolled into a program of elimination of major dietary lectins, consisting of all grains and pseudo grains, beans and legumes, peanuts, cashews, nightshades, squashes, and Casein A1 milk products (The Plant Paradox Program), supplemented with probiotics and prebiotics including resistant starches and polyphenol supplements. All pts initially low Vit D levels and low Omega 3 index and adiponectin levels above 16mg/dl. Biomarkers of inflammation, hs-CRP, TNF-alpha, IL-6, fibrinogen, myeloperoxidase and autoimmune markers were measured every 3 months.

95/102 patients achieved complete resolution of autoimmune markers and inflammatory markers within 9 months. The other 7/102 patients all had reduced markers, but incomplete resolution. 80/102 patients were weaned from all immunosuppressive and/or biologic medications without rebound.

We conclude that a lectin limited diet, supplemented with pro and prebiotics, and polyphenols are capable of curing or putting into remission most autoimmune diseases
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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Brian4 » Fri Aug 10, 2018 8:52 am

Fiver wrote:Looks like the link goes to a conference poster abstract, published in the journal's supplement section. There might be a companion paper out there somewhere. Sometimes they make it so confusing. IF there is a companion paper it could be embargoed for release at a future time.
It's not indexed in PubMed –

https://www.ncbi.nlm.nih.gov/pubmed/?te ... BAuthor%5D

– which it would be even if it were embargoed. In fact, it looks like Gundry hasn't had anything peer-reviewed since 2004 (the later papers in the above search are by a different Gundry). It's a shame that he's not doing real trials and submitting the results to journal peer-review. That would really help a lot of people.

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Tincup » Fri Aug 10, 2018 10:53 am

Brian4 wrote:– which it would be even if it were embargoed. In fact, it looks like Gundry hasn't had anything peer-reviewed since 2004 (the later papers in the above search are by a different Gundry). It's a shame that he's not doing real trials and submitting the results to journal peer-review. That would really help a lot of people.


Pretty much his MO as a very busy doc in private practice is to present either posters or presentations with an abstract. Clearly different than when he was at Loma Linda.
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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby ApropoE4 » Fri Aug 10, 2018 2:51 pm

He's a quack with books to sell.

Even if I were to believe his results (I don't at all), I'd assume they were related to weight loss and other lifestyle improvement, and not to his obsession with lectins.

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Julie G » Fri Aug 10, 2018 3:28 pm

Cut out the name calling, ApropoE4. You're welcome to express your opinion of the ideas that Dr. Gundry promotes, but we don't allow ad hominem attacks. Period. From our Community Guidelines:
Respect. All posts and private messages should be courteous. Disagree with ideas, not people. You may not attack, insult, undermine, or belittle anyone. This broad prohibition extends beyond other members and this community to the world at large.

Otherwise, nice to see you around ;).

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Re: New paper from Dr. Gundry on stopping progression of CAD

Postby Brian4 » Fri Aug 10, 2018 5:17 pm

ApropoE4 wrote:Even if I were to believe his results (I don't at all), I'd assume they were related to weight loss and other lifestyle improvement, and not to his obsession with lectins.
Yeah, most diet studies showing benefit in the experimental arm prove to be crypto-CR studies – or, to be precise: it cannot be ruled out they are crypto-CR studies. Amazing that so many researchers still don't know to do iso-caloric comparisons of different dietary constituents (and to make the studies "iso-exertional", etc., etc.). I can't say anything about Gundry's work because there aren't enough details, and, more importantly, I don't trust the work (work, not person! :mrgreen: ) of someone who refuses to subject it to peer-review.


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