Apparently (can't get full-text) the mice who ate once a day; both with and without CR yielded improved health regardless of the diet utilized. Of course, I want to know if a high fat diet was one of those trialed... From the graphics, it appears that 30% CR was the most beneficial, but eating once a day (all diets) also extended longevity. Can we assume that the benefits of autophagy persevered?"Increasing daily fasting times, without a reduction of calories and regardless of the type of diet consumed, resulted in overall improvements in health and survival in male mice," said de Cabo. "Perhaps this extended daily fasting period enables repair and maintenance mechanisms that would be absent in a continuous exposure to food."
Here's the paper:
Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
https://www.sciencedirect.com/science/a ... via%3Dihub
The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability.
