mike wrote:If ApoE4 is Neanderthal, then it seems like it would be useful to know what they ate. From the research, it looks like they ate pretty much whatever they could. In Northern climates, it was more meat, and in the south, more vegetables. And insects even. I'm not seeing anything about tubers though. It appears that they ate a VERY low carb diet for the most part, with seasonal fruit.
SunnySky wrote:Sorry, Mike. I wasn't clear.
This IS what we have:
My husband is 4/4 with 288 Neanderthal variants; which is more than 69% of 23&me customers.
Our daughter is APOE4 (heterozygous) with 303 Neanderthal variants; which is more than 87% of 23&me customers.
I do not have APOE4 and have 296 Neanderthal variants; which is more than 80% of 23&me customers.
circular wrote:On the other hand, since E4 is the ancestral allele in all primates (I think, right???), then there would have been a wide variety of both diets and food/fast cycles experienced by E4 populations. I don't think the small amount of Neanderthal DNA in us could be suggestive of how we should eat, and a closer look at what Neanderthal genes are being found in DTC testing suggests some of the other possible Neanderthal variants one might acquire may have more specific significance for us ....
circular wrote:I’m not sure, but I think they would already know whether Neanderthals had ApoE4. What I’ve read about is that certain of our HLA genes come from Neanderthals. I figure if Neanderthals were notably ApoE4 we’d already have heard it, but not sure. I think you must be right about that though?
Bernie wrote:Do you know which HLA genes have a Neanderthal heritage?
Verax wrote:The only data I could find online about Neanderthal ApoE4 is in the paper by McIntosh et al. (2012) "The Apolipoprotein E (APOE) Gene Appears Functionally Monomorphic in Chimpanzees (Pan troglodytes)" PLoS One. 2012; 7(10): e47760.
doi: 10.1371/journal.pone.0047760 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480407/ where alleles for rs429358 and rs7412 are "unknown." However, Denisovans according to this study were E4/E4, as were all humans (uniquely--chimps are not polygenic) until 300,000 to 200,000 years ago, when E3 and E2 arose. Currently earliest fossils of Neanderthals (derived from Homo erectus) in Europe are dated at 430,000 years ago, and thereafter Neanderthals expanded into Southwest and Central Asia, until they went extinct some 40,000 years ago.
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