RJones wrote:There is a Nordic Naturals product labeled "Omega 3 Phospholipids":
https://www.nordicnaturals.com/consumer ... spholipids
That seems like a good bet to me, and I take it, for what it's worth, but I'm not a health care professional by any means.
So it's just a suggestion, but multiple observations fit with the idea that ApoE4 enhances the response to inflammatory insults—again, great for Tsimane Indians, bad for older Americans/Europeans/etc. (a)
1) The MFI of Milan Fiala shows that those with AD do not phagocytose their Abeta. I believe they are “keeping it active” in the circulation so it can exert its antimicrobial effect. (b)
2) Multiple genes’ transcription reduced by ApoE4 transcriptional effect lead to increased inflammation when they are reduced. (c)
3) The metabolism you mentioned—same net effect. (d)
4) The transport effect Rhonda mentioned—same net effect. This may be related to #3 as an overall response but not necessarily by the same mechanism. (e)
So, as you mentioned, how do we counter these effects?
•Increase transportable omega-3 (fish or the formulation Rhonda mentioned).
•Increase dose of omega-3.
•Reduce all sources of inflammation, such as leaky gut. As you’ve been doing, it’s key to reduce anything that would activate the hair trigger of ApoE4 to produce inflammation.
•Help resolve ongoing inflammation, even if modest, with a trial of resolvins. (f)
•Keep omega-6:omega-3 ratio optimal (about 2:1 in blood). Avoid <1 (bleeding) and >4 or so. Perhaps this should be reduced to 1:1 given that the brain may not see the same ratio?
•Target specific pathogens, as you are doing.
•Consider including other anti-inflammatories such as ginger and curcumin.
f. https://www.metagenics.com/spm-active (Recommended in The End of Alzheimer’s, pg. 199)
Julie G wrote:Keep omega-6:omega-3 ratio optimal (about 2:1 in blood). Avoid <1 (bleeding) and >4 or so. Perhaps this should be reduced to 1:1 given that the brain may not see the same ratio?
BrianR wrote:Julie G wrote:Keep omega-6:omega-3 ratio optimal (about 2:1 in blood). Avoid <1 (bleeding) and >4 or so. Perhaps this should be reduced to 1:1 given that the brain may not see the same ratio?
Julie, is an omega-6:omega-3 ratio of 2 or less something that people regularly achieve with just a healthy diet?
apod wrote:I would be curious if there's any concern over the Neu5Gc content of fish roe (a complaint I've read about beef / red meat.) While ground beef and bison supply ~25-29ug/g of Neu5Gc, fish roe is in the 400-500ug/g range. From this perspective, a prophylactic 0.5oz serving of roe (which barely provides 1 gram of total polyunsaturated fats) would be about like eating a bison steak every day. https://www.ucdmc.ucdavis.edu/publish/n ... room/11551
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