Rhonda: So there is hope for a non-invasive clinically relevant biomarker for autophagy but there still, it seems like there needs to be more work done before that actually happen...before I can go to my doctor and say, "I did a four-day fast. I'd like to see if I've activated autophagy. Can you please draw some blood." Right? We're not quite there yet.
Dr. Kroemer: Yeah, it would be wonderful to have the reward of measuring autophagy as a result of fasting and to get an objective incentive as a biomarker for doing that.
How long do you have to fast for autophagy?
Autophagy is also achievable through intermittent fasting just as easily as longer fasts. Autophagy begins when liver glycogen is depleted, around 12-16 hours into a fast. The rate of autophagy peaks there, and then drops after about 2 days.
Even fasts of a few weeks or less can have dangerous consequences. Fasting puts two different types of stress on your heart. First, it cannibalizes cardiac muscle for fuel. The human body does everything it can to conserve muscle during a fast, but inevitably some muscle will be sacrificed at the beginning of the fast. After a few days, the body switches over to using fat, but researchers have discovered that protein (muscle) utilization actually increases again later on, even though fat stores are still available. This protein includes the muscle in your heart: weaken this too much, and heart failure will result.
Just hold on loosely
But don't let go
If you cling too tight babe
You're gonna lose it
You're gonna, lose control
PeterM wrote:I have wondered about the autophagy question for some time. Like Brian I have never had any luck locating research that pins down the minimum number of hours necessary to kick start autophagy. For those interested there is a free online ebook(let) by Ron Migerny (a biology Phd) that deals exclusively with an autophagy approach to delaying degenerative neurological diseases. It's definitely worth a look if you have 15 min. It's broken down into super short chapters many of which can be skimmed or simply passed over. 7-8 pages of reading, max. The guy might be on to something.
https://proteincyclingdiet.wordpress.co ... rwklbxs-1/
The upshot is all neuro diseases are primarily misfolded protein diseases and if you sufficiently restrict protein often enough, you can control the doubling of misfolded proteins that eventually overwhelm the cell. His contention is by keeping protein under 4% you can have your autophagy yet eat too, be it carbs or fat. Just avoid a certain threshold of protein for anywhere between 18-72 hr, then replenish protein. Younger (or more fortunate) people with intact metabolic flexibility might go a low-protein form of carbs route, the rest of us choosing salads, olive oil, avocados, macadamias etc. In any case, it's an easy read, interesting theory, and has plenty of ways to approach diet. Excuse this if it's been addressed before. Couldn't find any reference in Search.
Autophagy is more active several hours after our last meal (after several hours of fasting and before the first bite of the day), and then slows down when we eat. Time-restricted eating is known to increase autophagy for a few hours during the fasting period.
Users browsing this forum: No registered users and 3 guests