From Science News: New methods to identify Alzheimer's drug candidates with anti-aging properties
Actual paper:... New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
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The team started with two chemicals found in plants that have demonstrated medicinal properties: fisetin, a natural product derived from fruits and vegetables, and curcumin, from the curry spice turmeric. From these, the team synthesized three AD drug candidates based upon their ability to protect neurons from multiple toxicities associated with the aging brain. The lab showed that these three synthetic candidates (known as CMS121, CAD31 and J147), as well as fisetin and curcumin, reduced the molecular markers of aging, as well as dementia, and extended the median lifespan of mice or flies.
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Importantly, the group demonstrated that the molecular pathways engaged by these AD drug candidates are the same as two other well-researched synthetic compounds [metformin and rapamycin] that are known to extend the lifespan of many animals. For this reason, and based on the results of their previous studies, the team says fisetin, curcumin and the three AD drug candidates all meet the definition of being geroneuroprotectors.
David Schubert, Antonio Currais, Joshua Goldberg, Kim Finley, Michael Petrascheck, Pamela Maher. Geroneuroprotectors: Effective Geroprotectors for the Brain. Trends in Pharmacological Sciences, 2018; DOI: 10.1016/j.tips.2018.09.008
Nice diagram from the paper:
