I think this is an important meta-analysis that we should all take note of, so I copied and pasted this from the abstract:Plumster wrote:Try to get Vitamin A from whole foods like vegetables and fruits (or meat sources). This study concludes that taking vitamin A supplements may increase mortality:
"DATA EXTRACTION: We included 68 randomized trials with 232 606 participants (385 publications). DATA SYNTHESIS:
When all low- and high-bias risk trials of antioxidant supplements were pooled together there was no significant effect on mortality (RR, 1.02; 95% CI, 0.98-1.06). Multivariate meta-regression analyses showed that low-bias risk trials (RR, 1.16; 95% CI, 1.04[corrected]-1.29) and selenium (RR, 0.998; 95% CI, 0.997-0.9995) were significantly associated with mortality. In 47 low-bias trials with 180 938 participants, the antioxidant supplements significantly increased mortality (RR, 1.05; 95% CI, 1.02-1.08). In low-bias risk trials, after exclusion of selenium trials, beta carotene (RR, 1.07; 95% CI, 1.02-1.11), vitamin A (RR, 1.16; 95% CI, 1.10-1.24), and vitamin E (RR, 1.04; 95% CI, 1.01-1.07), singly or combined, significantly increased mortality. Vitamin C and selenium had no significant effect on mortality."
Julie G wrote:Thanks for sharing this Julie! I am TT for the rs12934922 SNP. I appear to not be deficient in any of the others. A big part of why I eat sweet potato is that they are absolutely loaded with vitamin A. 1 cup of sweet potato has nearly 19,000 IU of Vitamin A.
Happy to help! I think this may be important for us. My understanding is that a cup of sweet potato actually has no vitamin A. The conversion from beta-carotene to Vitamin A happens in your body and TT means that you convert poorly. Maybe higher amounts of beta-carotene will get the job done? Foods like liver and cod liver oil have actual vitamin A.
It took a while but I was able to get my Vitamin A tested. It turns out I am fine. According to LabCorp <20ug/dL is considered low and my current amount is 43.7 ug/dL. I do eat a lot of sweet potatoes so I guess there's a chance I do convert poorly and I get enough beta carotene to keep my A levels fairly high. For the record I do not take cod liver oil.
Julie G wrote:It took a while but I was able to get my Vitamin A tested. It turns out I am fine. According to LabCorp <20ug/dL is considered low and my current amount is 43.7 ug/dL. I do eat a lot of sweet potatoes so I guess there's a chance I do convert poorly and I get enough beta carotene to keep my A levels fairly high. For the record I do not take cod liver oil.
Nice, SoCalGuy! Thanks for sharing with us. You may want to plug your number into the paper above to see how you compare to their dataset. From my untrained eye, your level, converted to 2.11 umol/L, seems to be correlated with the "normal" cognition group. Kudos!
Would you mind sharing how much sweet potato or carrots you eat per day? Also, give us an idea of your general age & state of health, both of which can play a part in being able to make the conversion.
Brainstormer wrote:Julie - thank you so much for posting these findings and to read all the related comments. My issue is that I'm allergic to all forms of fish so supplementing with cod liver oil isn't an option but I eat tons of veggies so hope I'm getting enough that way. All this has encouraged me to go back to my extrapolated 23&me results and dig into these snp's a bit!
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