Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

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BrianR
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Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

Post by BrianR »

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.
Rajabli F, Feliciano BE, Celis K, Hamilton-Nelson KL, Whitehead PL, Adams LD, et al. (2018)
PLoS Genet 14(12): e1007791. https://doi.org/10.1371/journal.pgen.1007791

Interesting.
Discussion
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Our findings suggest that the ApoE region from AF [African] populations may contain protective factors that help mitigate the effect of the ε4 allele. In particular, comprehensive analysis of the ApoE region and testing for protective loci may reveal previously unappreciated biological pathways and provide translational opportunities. Research that focuses on locating protective variants represents a complementary approach to accelerating the identification of more effective targets for drug development. This, in turn, will lead to better treatments, and help reduce health disparities.
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