Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease

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BrianR
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Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease

Postby BrianR » Mon Feb 11, 2019 4:51 pm

After listening to the Peter Attia interview with Francisco Gonzalez-Lima yesterday, I thought this was relevant.

The paywalled article is:
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models
https://www.nature.com/articles/s41593-018-0329-4
https://doi.org/10.1038/s41593-018-0329-4


You can also read the freely available Science Daily summary: New Alzheimer's therapy with brain blood flow discovery?

Interesting extract from the Discussion
Capillary obstruction due to tissue inflammation has been observed in a variety of organ systems (typically at higher incidence than observed here), and has been shown to contribute to the development of pathology and disease33–39. Inflammation is a persistent and well-recognized feature of Alzheimer’s disease, and previous work has demonstrated an increase in inflammatory adhesion receptors on endothelial cells40–42, which probably underlies the capillary stalling we observed. A major contributor to this inflammation is increased reactive oxygen species induced by brain exposure to Aβ oligomeric aggregates26. These reactive oxygen species cause a loss of cerebrovascular flow regulation and probably drive the expression of leukocyte-binding receptors on the endothelial cell surface, such as ICAM1 and VCAM1. Our observation that certain capillary segments were more likely to stall suggests that the underlying vascular inflammation may not be uniform.

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Re: Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s dise

Postby aphorist » Mon Feb 11, 2019 6:31 pm

Interesting. I played w/ methylene blue a bit after that podcast. It's very annoying that it stains everything. I need to find a pill form, if you know any.

Another consideration is Ginkgo or maybe low dose Telmisartan.

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Re: Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s dise

Postby StevenL » Thu Feb 14, 2019 1:25 pm

I thought this interview was VERY enlightening. I got more out of it than the other ones I've checked out. And his theories do not conflict with what Bredeson is saying about multiple pathways to AD. If in the end it's a blood flow problem in a certain areas of the brain, anything that effects that will be a pathway; Metabolic issues/CVD (vascular side)/infectious damage/trauma and anything else.

Edit: To be more specific, as Attia summarizes, "Gonzalez-Lima explains "the vascular hypothesis of Alzheimer’s disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration."

Thus anything that:
stops slows or reverses impairment of blood flow and/or
facilitates adequate mitochondrial respiration
Is of interest for prevention and treatment of AD.

And the Methylene Blue info is golden!


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