The paywalled article is:
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models
You can also read the freely available Science Daily summary: New Alzheimer's therapy with brain blood flow discovery?
Interesting extract from the Discussion
Capillary obstruction due to tissue inflammation has been observed in a variety of organ systems (typically at higher incidence than observed here), and has been shown to contribute to the development of pathology and disease33–39. Inflammation is a persistent and well-recognized feature of Alzheimer’s disease, and previous work has demonstrated an increase in inflammatory adhesion receptors on endothelial cells40–42, which probably underlies the capillary stalling we observed. A major contributor to this inflammation is increased reactive oxygen species induced by brain exposure to Aβ oligomeric aggregates26. These reactive oxygen species cause a loss of cerebrovascular flow regulation and probably drive the expression of leukocyte-binding receptors on the endothelial cell surface, such as ICAM1 and VCAM1. Our observation that certain capillary segments were more likely to stall suggests that the underlying vascular inflammation may not be uniform.