Are we tackling elevated homocysteine the wrong way?

[Julie G]

In a recent blog post, Chris Masterjohn makes an eloquent argument that a riboflavin deficiency may be what's provoking elevated homocysteine for those of us with some form of the MTHFR polymorphism, about 85-90% of the population. This may explain the inconsistent results many of us get when supplementing with B-12, folate and B-6. More here.

[TheresaB]

No time to dive into this now, but thank you for sharing, this sounds very interesting.

[Plumster]

After doing the Nutreval Genova Diagnostics vitamins test last year, I realized I was severely low in B2. In fact, it explained why I was having random eye inflammations and perhaps also why I couldn't handle methylfolate (although I was also very low on magnesium). There's a diagram in the test that shows just how important B2, magnesium, and zinc are for methylation. So I've been taking B2 and magnesium every day since. There's a particular MTHFR variation that strongly benefits from taking B2 to lower homocysteine (maybe C677T++?). I was reading research on it last year. B2 is the cofactor for MTR, MTRR, MTHFR, so if you've got methylation blockages here, it makes sense to get sufficient B2.

[CoachDD]

I saw this too. . . very interesting! Thank you for sharing here!