Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

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Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby BrianR » Tue Apr 02, 2019 9:19 am

No real news, but clearly explained:

https://www.nytimes.com/2019/04/02/health/klotho-brain-enhancement-dementia-alzheimers.html

APOE4 germane section:
In March, Dr. Dubal and her colleagues published a study suggesting that Klotho may also provide some protection from Alzheimer’s disease to people as well.

One of the biggest risk factors for Alzheimer’s disease is a genetic variant called APOE e4. Inheriting two copies of the gene can increase the risk more than eightfold.

Dr. Dubal and her colleagues found that many people with APOE e4 appeared to be on their way to Alzheimer’s disease even if they had no sign of dementia yet. They had markers indicating a buildup of clumps in their brains.

Then Dr. Dubal and her colleagues looked at the people with both APOE e4 and extra Klotho. They had no extra clumps.

It’s possible that in these people Klotho is slowing the effects of carrying APOE e4, Dr. Dubal speculated. “Maybe their brains are biologically younger,” she said.

A few other research groups have also found promising results in people, but all of the studies — Dr. Dubal’s included — are small.

but
Dr. King doesn’t dispute the remarkable results of the Klotho experiments. It’s just that researchers can’t account for them.

When Dr. Dubal injects Klotho into mice, for example, the hormone doesn’t actually get into the brain. It must trigger some series of reactions in the body — but no one can say what they are.

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby Julie G » Tue Apr 02, 2019 10:10 am

Sign me up! A simple shot in the belly to avoid AD... and be smarter. :D YES, please

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby Creekside » Fri Apr 05, 2019 10:18 am

Julie G wrote:Sign me up! A simple shot in the belly to avoid AD... and be smarter. :D YES, please


Me, too!

(Hmmm...I wonder if it is possible to check Klotho status using 23andme data?)

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Re: RE: Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby Stavia » Fri Apr 05, 2019 12:26 pm

Creekside wrote:
Julie G wrote:Sign me up! A simple shot in the belly to avoid AD... and be smarter. :D YES, please


Me, too!

(Hmmm...I wonder if it is possible to check Klotho status using 23andme data?)
Yes there is. Have a look on snpedia for the rs number. Or search our forum - a few years ago some of us were brave enough to look at our Klotho status.

Sent from my SM-N960F using Tapatalk

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby ru442 » Fri Apr 05, 2019 12:36 pm

It's rs9536314... and I don't have it ;)
Male 4/4 55 yrs., "Live, Laugh, Love"

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby Creekside » Fri Apr 05, 2019 2:36 pm

ru442 wrote:It's rs9536314... and I don't have it ;)


Me neither. :x

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby NF52 » Fri Apr 05, 2019 2:56 pm

Creekside wrote:
ru442 wrote:It's rs9536314... and I don't have it ;)


Me neither. :x
Me neither, but my husband does and his dad lived to 90, which was 42 years more than the 2 months to live his doctors gave him after surgery and a diagnosis of "terminal" colon and liver cancer at age 48. He also survived prostate cancer and quadruple bypass in his 80's. I used to say that they ought to figure out what was in his dad's DNA--now it looks like they have!
4/4 and still an optimist!

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Re: Carl Zimmer on Klotho: "One Day There May Be a Drug to Turbocharge the Brain. Who Should Get It?"

Postby Matisse » Fri Apr 05, 2019 10:36 pm

I have it and my parents lived to 73 and 49, both dying from cancer.


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