When I first posted this I wasn't able to pull up full text, but now I can:Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells
The human treatment group (only n=12
) used just 2 gms (about 1/4-1/2 tsp) of baking soda per 8.5 cups of water.
To determine whether oral NaHCO3 had a similar anti-inflammatory action in humans as we found in rats, we evaluated blood samples at baseline and 1, 2, and 3 h following ingestion of a single dose (2 g) of NaHCO3 (n = 11) or equimolar NaCl (n = 6), each dissolved in 250 ml of bottled water. Pre- and posttreatment values of serum electrolytes are presented in Table III. There was a significant group by time interaction for changes in serum potassium (p = 0.029, η2P = 0.279). Specifically, serum potassium decreased with NaHCO3 treatment (p = 0.008), but there was no change with NaCl treatment (p = 0.381). BMI and C-reactive protein levels were not significantly different at baseline between either group, indicating a similar baseline inflammatory state (Table IV). No other significant differences were observed between TXT groups at baseline in any variables tested (Table IV)...
Baseline flow cytometry values of all subjects, before ingesting NaHCO3 or NaCl in solution, are presented in Table IV. Prior to any treatment, the percentages of blood leukocytes that were TNF-α+ neutrophils, M1 macrophages, or M2 macrophages were all significantly higher in the NaHCO3 TXT group when compared with baseline values obtained in the NaCl TXT group (Table IV). There was a significant TREATMENT × TIME effect on both M1 macrophages (p = 0.0004) and TNF-α–positive neutrophils (p = 0.0146), with the levels of these inflammatory cells in the plasma being reduced to a significantly greater degree following ingestion of NaHCO3 when compared with NaCl (Fig. 3). The greatest decreases in blood inflammatory cells were observed at 2 and 3 h following NaHCO3 ingestion. Similar to our observations in rats, oral NaHCO3 ingestion increased the percentage of blood leukocytes identified by flow cytometry as M2 macrophages (p = 0.00165) (Fig. 3). Decreases in inflammatory TNF-α+ neutrophils and M1 macrophages in the NaHCO3 TXT group did not appear to be related to the differing baseline levels observed between TXT groups. When comparing individual responses between subjects of different groups, subjects with similar baseline levels of blood leukocytes responded differently if they received NaHCO3 compared with NaCl (Supplemental Fig. 1)...
[Interstingly] the gastric proton pump inhibitor esomeprazole also inhibited the anti-inflammatory response to NaHCO3 (Fig. 6). [Emphasis added]
There's much more for a deep dive.
Of course the small study size is a problem, and if the greatest difference is 2 and 3 hours after ingestion, maybe hypothetically it would need to be taken every six hours or so.
Unfortunately they didn't track hs-CRP. Since the effect was so fast, I'm inclined to down some 2.5 hours before an hsCRP blood draw out of curiosity, but I'm not sure the if the mechanism targeted would impact hsCRP at all or as fast.
Playing in my sandbox ...
ApoE 3/4 > Thanks in advance for any responses made to my posts.