Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise
Research in context
1.Systematic review: Review of the literature shows self-reported physical activity is associated with better cognitive and physical performance in healthy elderly who carry the APOE ε4 allele.
2.Interpretation: In a post hoc analysis of a large multicenter study, we find that patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from an exercise intervention on cognitive, neuropsychiatric, and physical measures compared to patients with Alzheimer's disease who do not carry the APOE ε4 allele.
3.Future directions: These results need to be validated in larger studies. If positive, this knowledge could greatly impact the clinical management of Alzheimer's disease.
I would be interested to know what others are doing to optimize their exercise prescription.