Welcome, jgreg80!Jgreg80 wrote:Hi all, came across this and figured I’d post it here
The top ApoE4 protective SNP (ISYNA1, rs2303697) is genotyped by AncestryDNA and isn’t rare (minor allele frequency 0.35 in Europeans). Now just have to find someone with JAMA access to see how substantial the odds ratio is...
Unfortunately, it's not part of the 23&me analysis I had done.Among ApoE4 carriers, the top SNP in ISYNA1, rs2303697, protected in all cohorts except CHARGE.
[Emphasis added.][John Hardy of University College, London] added that the error rate of AD diagnoses, upon which the AD risk associations rely, further complicates the findings.
Farrer said that all variants identified in ADSP will be put to the test in larger, whole genome sequencing cohorts. The Alzheimer’s Disease Genomic Consortium aims to sequence the whole genomes of at least quadruple the number of people included in the current ADSP WES analysis, Farrer said. “We are in the middle of an ongoing saga of filling in the genetic architecture of AD, which clearly is not accounted for by common variants.”
xactly wrote:I cannot find the rs2303697 SNP in the SNPedia, but my 23andme data shows I have C/T at that point. From other posts, I see that the T allele is protective (i.e., reduces the accumulation of myoinositol in the brain). Does anyone know if the wild type is T/T? I'm not well versed in this, but looking at the dbSNP data, it looks like the variation is from T to C. If I'm interpreting this correctly, and the wild type is T/T, T/T allele would provide greater protection for APOE4 carriers than C/T.
xactly wrote:Matisse wrote:I don't see this on the V3, V4 or V5 platform of 23andme. How did you find it?
I was genotyped with the V3 chip. When I searched for the SNP in Raw Data, it showed up.
Jgreg80 wrote:Found the full article -
The odds ratio for the minor T allele of rs2303697 is O.73. A 27% reduction in AD for us ApoE4’s, I’ll take it.
Btw, It’s genotyped by AncestryDNA v2.
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