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More info on why APOe4 may be worse for women-And what you can do about it.

Posted: Sun Jun 30, 2019 9:28 am
by Michae_M
Make sure you are getting ample amounts of DHA..

Our findings show a strong association between age, female sex, and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, which together may contribute to the development of cognitive decline and AD pathology.


https://www.ncbi.nlm.nih.gov/pubmed/31251078

Specialized Pro-Resolving Mediators or "SPM's" are essential to the resolution of inflammation and may not be present in as high concentrations in the brains of APOE4 females due to the lower concentration of the precursor DHA. Studies suggest SPM levels can be raised in human by dietary measures.

Given the potent biological actions of SPM in organ protection and promoting bacterial clearance, nutritional therapies enriched in omega-3 fatty acids hold promise as a potential co-therapy approach when coupled with functional lipid mediator profiling.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884427/

Plasma concentrations of biologically active oxylipins derived from n-3 PUFAs, including epoxy-PUFAs and SPM-precursors, increase linearly with elevated intake of EPA and DHA. Interindividual differences in resulting plasma concentrations are low


https://www.ncbi.nlm.nih.gov/pubmed/31006007

Fish oil increases SPMs in plasma of patients with PAD. Further studies are required to determine whether these early changes translate to clinical improvements in patients with PAD.


https://www.ncbi.nlm.nih.gov/pubmed/30771686

Re: More info on why APOe4 may be worse for women-And what you can do about it.

Posted: Sun Jun 30, 2019 11:19 am
by NF52
Michae_M wrote:Make sure you are getting ample amounts of DHA..
Our findings show a strong association between age, female sex, and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, which together may contribute to the development of cognitive decline and AD pathology.

https://www.ncbi.nlm.nih.gov/pubmed/31251078

Specialized Pro-Resolving Mediators or "SPM's" are essential to the resolution of inflammation and may not be present in as high concentrations in the brains of APOE4 females due to the lower concentration of the precursor DHA. Studies suggest SPM levels can be raised in human by dietary measures.
Given the potent biological actions of SPM in organ protection and promoting bacterial clearance, nutritional therapies enriched in omega-3 fatty acids hold promise as a potential co-therapy approach when coupled with functional lipid mediator profiling.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884427/
Plasma concentrations of biologically active oxylipins derived from n-3 PUFAs, including epoxy-PUFAs and SPM-precursors, increase linearly with elevated intake of EPA and DHA. Interindividual differences in resulting plasma concentrations are low

https://www.ncbi.nlm.nih.gov/pubmed/31006007
Fish oil increases SPMs in plasma of patients with PAD. Further studies are required to determine whether these early changes translate to clinical improvements in patients with PAD.

https://www.ncbi.nlm.nih.gov/pubmed/30771686
Thanks for finding and sharing these sources, Michae_M. They reinforce the view that women's health is not necessarily well-served by the habits of past research that often focused heavily on male subjects, and that both men and women need to consider how to balance natural sources of DHA and other fatty acids with supplements as needed. Here's our wiki on the subject:
https://www.apoe4.info/wiki/Omega-3_fatty_acids

Re: More info on why APOe4 may be worse for women-And what you can do about it.

Posted: Mon Jul 01, 2019 7:10 am
by frankiesfriend
Is there any evidence that tau accumulation is reversed by lifestyle changes embodied in RECODE, or are the improvments observed in early AD by following the Bredesen protocol compensatory to a fixed pathology?