Yes, Asia- there IS evidence to suggest that post-menopausal E4 women ARE at increased risk of CAD. http://atvb.ahajournals.org/content/14/7/1105.long
CONCLUSIONS: "The lower frequency of the e4 allele in older subjects, which is more evident in women than in men, could be related to the stronger impact of the E isoforms in postmenopausal women than in older men. Our results indicate that the sharp increase in LDL cholesterol levels occurring in women after menopause may be accentuated by the presence of the E4 isoform. In fact, menopause in women with the E3/2, E3/3, and E3/4 phenotype was associated with a 9%, 21%, and 26% increase, respectively, in LDL cholesterol levels.
COMMENTS:It is remarkable how similar E4 lipids are to other genotypes in this older observational study, UNTIL it comes to post-menopausal women. Then, we see a dramatic jump in both LDL and Apo-B. This could be the basis of a strong argument for E4 women to use HRT therapy if possible.
Early menopause for me, around 48 y/o. Interestingly, when I learned of my 4/4 status and began to eat a whole food diet with more dietary fat; menses returned for me
Cholesterol is a precursor to hormones. I poked around a bit and learned that a Paleo type of diet is sometimes recommended for fertility:http://thepaleodiet.com/fertility-incre ... onception/