E4s Have Earlier Menopause Onset?

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
Lisa in LJ
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Re: E4s Have Earlier Menopause Onset?

Postby Lisa in LJ » Fri Aug 08, 2014 7:41 am

I'm not sure how old my mom was, but she was well over 50. I'll never know how old I was/will be. I had a hysterectomy at 38.

SweetSue
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Re: E4s Have Earlier Menopause Onset?

Postby SweetSue » Fri Aug 08, 2014 11:23 am

Yes for me. I was around 48 when my OBGYN said I have the hormone levels of a 65yo. :cry:

RedNailz
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Re: E4s Have Earlier Menopause Onset?

Postby RedNailz » Fri Aug 08, 2014 10:02 pm

I don't know how old my mom was, but my sister went through menopause at about 50. At 44, I have signs of perimenopause, right on schedule according to my doctor.
4/4

Gina99
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Re: E4s Have Earlier Menopause Onset?

Postby Gina99 » Sun Aug 10, 2014 12:31 pm

53 for me, mother 4/4 about the same. she had no issues one day it stopped she said. Me suffered for 10 months, almost quit my job. Sister 3/4 with AD early 50's as well.

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Re: E4s Have Earlier Menopause Onset?

Postby hairyfairy » Mon Apr 01, 2019 3:13 pm

I tried hrt a few years ago, but it made my cholesterol soar.

Creekside
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Re: E4s Have Earlier Menopause Onset?

Postby Creekside » Mon Apr 01, 2019 6:15 pm

3/4 and not in menopause until I was 57.

JudyH
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Re: E4s Have Earlier Menopause Onset?

Postby JudyH » Mon Apr 01, 2019 6:56 pm

3/4 and also almost 57. My ob/gyn labeled me late menopausal!
e3/e4
No family history of AD, they drop dead of heart attacks in their early 40's!
Celiac and Hashimotos

Plumster
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Re: E4s Have Earlier Menopause Onset?

Postby Plumster » Tue Apr 02, 2019 7:13 am

We should probably also consider how many 9-month pregnancies we've each had as that'll delay menopause by a few years.
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR

Creekside
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Re: E4s Have Earlier Menopause Onset?

Postby Creekside » Fri Apr 05, 2019 10:01 am

Age of onset of menopause is also influenced/associated (somehow) by birth month. My birth month of October rather perfectly fit their findings.

https://www.ncbi.nlm.nih.gov/pubmed/15890738

"Age at menopause of 2822 post-menopausal women (>12 months of amenorrhoea) was stratified by month and season of birth. Mean age at menopause was 49.42 years (SEM: 0.78 years). Menopause occurred earlier for women born in the spring (age 49.04+/-0.15 years) than in the autumn (49.97+/-0.14 years). The earliest menopause was found in women born in March (48.9+/-0.25 years) and the latest in women born in October (50.3+/-0.25 years). The effect of season of birth on age at menopause remained even when considering factors that in our analysis were capable of significantly interfering with the timing of menopause, such as age at menarche, body mass index, smoking habit, level of education and type of job."

FWIW, I had pretty much a non-issue menopause -- some hot flashes, but nothing like most of my friends went through. They were generally years younger than I was at the time they started -- maybe it was a function of going down a steep hill in their case vs. a more gentle decline in mine? Never took HRT.

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Re: E4s Have Earlier Menopause Onset?

Postby Anna » Sat Apr 06, 2019 9:47 pm

I'm curious as to WHY ApoE4 might cause earlier menopause.

I'm 4/4 and had surgical menopause at 50, so all I know is I wasn't early, in spite of having been told to expect early menopause due to only having had one ovary and having had surgery on the other. What I do know is that my brain could not handle the sudden drop in estrogen, even with the standard ERT dose. I had major dizzy spells and brain fog, and I shed many tears; all of these symptoms disappeared with an increased dose. I now wonder if this was somehow related to my ApoE status.
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4/4 but so much more


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