https://ehp.niehs.nih.gov/doi/full/10.1289/EHP4599
Due to concerns about its safety, the use of bisphenol A (BPA) has been restricted, and structural analogs, especially bisphenol S (BPS), have mainly replaced BPA in consumer products. BPS has thus been detected in 89.4% of urine samples from a representative cohort of the U.S. population.
Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds. Given the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health.
