Bomag wrote:I'm a 4/4 and my childhood IQ was measured in the 140s. Never had any trouble learning stuff. I have lots of other problems I associate with APOE 4/4, but not intelligence.
HI again, Bomag,
Your IQ would put you in the top 1% of people, a "1 percenter" status you can be happy to have, since it gives you a hefty brain account of "cognitive reserve" and likely "brain resilience" to draw upon for decades.
As a participant in the Generations 1 Stage 3 clinical drug trial for healthy individuals with ApoE 4/4, I have had cognitive test batteries for 3 years. Because the trial was halted, I was able to find out how I did on those tests and will find out if I was on the drug or placebo in a few months. I have not changed at all on multiple cognitive measures during the last three years and think that's great news at almost age 68. It suggests that many small, early studies of ApoE 4, based on people diagnosed with dementia, vastly under-estimated the likelihood of continuing to have a healthy brain into our 70's and beyond.
You may be surprised to know that researchers are looking for people like us with health brains and curious minds. They also realize that people want to be active participants and gain as much information as possible while participating in a trial.
If you're interested in finding out more about study opportunities, here's some info:
The All of Us Research Program
is sponsored by the National Institute of Health: All of Us
inviting one million people across the U.S. to help build one of the most diverse health databases in history. We welcome participants from all backgrounds. Researchers will use the data to learn how our biology, lifestyle, and environment affect health. This could help them develop better treatments and ways to prevent different diseases.
The Alzheimer's Association spends millions each year to support research on prevention and treatment of AD, and has a Trial Match of studies that include non-drug trials. You can read more here: Trial Match
The Alzheimer's Clinical Trial Consortium (ACTC) is a network of dozens of academic research centers collaborating to accelerate research, with funding from the National Institute on Aging (NIA/NIH). They have an online Alzheimer's Prevention Trial web study called for people who are 50 years or older. You can find information about it here: APT Webstudy Welcome
(Full disclosure: I am on the Research Participant Advisory Board for the ACTC, although I am not in any ACTC-sponsored clinical trial.)
Enjoy re-writing the story line for ApoE 4 and IQ's!