'dentification of dietary phosphatidylcholine metabolites as markers for increased CVD risk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086762/
'dentification of dietary phosphatidylcholine metabolites as markers for increased CVD risk
The take-away for me:Highlights
•One-carbon metabolism and the APOEε4 allele variant could interact in dementia.
•This potential interaction has not been addressed in prognostic dementia studies.
•We measured metabolites in sera in a longitudinal study on cognition in dementia.
•Choline oxidation metabolites seem to improve cognitive prognosis in APOEε4 carriers.
•In comparison, they may be detrimental to cognitive prognosis in non-carriers.
Interestingly however, our data suggests that higher concentrations of components of the choline oxidation pathway may be of benefit to patients with APOEε4, but potentially detrimental to patients without this allele.
Ah but assumptions can throw a spanner in the works. My maternal side has the AD but my mother, who also had it, was 3/3. I wish I could find out what those before her had in their genetics. I'm saving all the stamps I can in case DNA on them can ever be extracted or inferred at an affordable cost. It would be interesting if they were all 3/3, since it could suggest some other strong risk genetics at play with a mechanism worth elucidating.Jafa wrote:I have assumed I am ApoE4 as I have a strong maternal family history of dementia...
first time asking a question on this forum. i have one apoe4, do not know what the other is. I am 63 yo woman. My cholesterol prior to menopause was good, when i was under 40 it was great. now i am borderline and heading in the wrong direction. I thought that egg yolks especially would be bad for me and am confused with the high number of eggs consumed. I have known about this gene for 2 years, have gone on elimination diet and felt good but doc office visit with cholesterol heading in wrong direction when i thought i was doing everything right is frustrating, confusing etc.Julie G wrote:No, sorry. You win, even from amongst the FaceBook crowd. Only one gal matched your requirement. At least we know that you come by your “methylation whisperer” title honestly.Anybody else out there that beats 9? Please? Please someone make me feel better about my whacked methylation pathways...
Hi sunrise, and welcome. Since I'm the party of needing 9 eggs, let me make just a couple comments. I'm also a 3/4 and postmenopausal. I saw my lipids change quite a bit from my 40s, too.sunrise wrote:Any suggestions for whose approach is gospel for APOE4 1 copy?
Hi sunrise! When I read the line of yours that I quote here, I really laughed because I have been there, and think “feel like my head is in a washing machine” is a perfect simile. All that information swishing and churning and one piece getting tangled up with another. SusanJ’s suggestions seem like a really good approach to figuring out what is right for you. From my perspective, there is no one whose approach Is “gospel” for those who carry ApoE4. There are individuals who strictly adhere to Dr Gundry or Dr Perlmutter or Dr Amens or Dr Bredesen, but for many of us, we are combining approaches , drawing from many sources, and creating plans that work for us individually. Even “what works” might be defined differently for different people. Personally, I am comfortable with higher lipid numbers. Whether or not that approach is working is something I hope to determine with a CAC test. ( I have been on a waiting list for 6 months. My “healthy person” concerns are way down the line in my state’s overwhelmed health care system.)sunrise wrote: I have read Bredesen, gundry, hyman, perlmutter, lugavere and feel like my head is in a washing machine. Any suggestions for whose approach is gospel for APOE4 1 copy?