a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

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BrianR
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a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

Post by BrianR »

The more readable discussion of this research from Science Daily:

An alternate theory for what causes Alzheimer's disease
https://www.sciencedaily.com/releases/2 ... 144930.htm

The actual paper (open access) is:
Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease
https://pubs.acs.org/doi/10.1021/acscentsci.9b00369#
Tyler R. Lambeth, Dylan L. Riggs. Lance E. Talbert, Jin Tang. Emily Coburn, Amrik S. Kang. Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian
ACS Central Science, 2019; DOI: 10.1021/acscentsci.9b00369
Synopsis
Spontaneous chemical modifications to long-lived proteins, isomerization and epimerization, prevent degradation in the lysosome and may account for related pathology observed in Alzheimer’s disease.
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