ru442 wrote:This is way above my pay grade, but looks like promising work on detecting onset of AD. Maybe one of our science peeps can explain in laymen terms:
ETA: Ok this article dumbed it down enough for me to understand:
https://medicalxpress.com/news/2019-08- ... sease.html
Fiver wrote:They found differences in how the genes were marked, and how these marks changed over time, in the EOAD and LOAD cell types, compared to controls. THis is really cool. First, it suggests that these genes are indeed important. Second, it suggests that HOW AND WHEN THE GENES ARE EXPRESSED is controllable by epigenetics, e.g. methylation. This means that - in theory - even those will problematic genes may be able to control their expression in a way that makes them less problematic.
Fiver wrote:The key, of course, is knowing whether or not one would want more or less methylation on specific genes, at specific times. And how to accomplish that. I'd have to read more to figure that out.
SusanJ wrote:Fiver wrote:
SusanJ wrote:I'd surely be looking at those genes as far as do the methylation changes represent gain or loss of function. And can that be manipulated somehow. Million dollar questions for sure.
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